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Fig. 7 | BMC Cancer

Fig. 7

From: Comparative transcriptomics reveals similarities and differences between astrocytoma grades

Fig. 7

Transcriptional regulatory network distinguishing PA I from AS II, AS III and GBM IV. TFs are displayed by labeled circles. The circle size increases with the number of outgoing regulatory edges to other signature genes highlighting major regulators by large circles. The color coding of the circle represents the average expression level of the corresponding gene in AS II, AS III and GBM IV diagnosed in adults relative to PA I diagnosed in children and young adults: underexpressed (blue) and overexpressed (red) in adult astrocytomas. Inferred regulatory dependencies between TFs and signature genes are displayed by directed edges: activator (orange) and repressor (purple)

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