Fig. 5

Transcriptional alterations of cytokine-cytokine receptor interaction pathway genes comparing PA I and GBM IV. Representation of under- and overexpressed cytokine-cytokine receptor interaction pathway genes identified in PA I and GBM IV in comparison to normal brain tissue. The basic pathway map (hsa:04060) was generated using KEGG [130] and manually modified. Genes are colored according to their observed expression level (i) genes only overexpressed in PA I (light blue), (ii) genes only underexpressed in GBM IV (red), (iii) genes only overexpressed in GBM IV (orange), (iv) genes commonly overexpressed in PA I and GBM IV (grey), except for KIT that was underexpressed in both tumor types, (v) CX3CL1 overexpressed in PA I and underexpressed in GBM IV (green), (vi) genes that were not present on the microarray (purple), and (vii) genes with unchanged expression levels (white)