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Fig. 6 | BMC Cancer

Fig. 6

From: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

Fig. 6

KPT-330 inhibits prostate tumor growth in vivo. Once tumors were established (80–100 mm3 in size), mice were divided into four different groups (10 mice/group) and treated with varying doses of KPT-251 (5, 10, 20 mg/Kg Mondays, Wednesdays and Fridays PO). Tumor volumes were calculated as indicated in MM and follow for 35 days. Group means were calculated and are shown with error bars representing SD for each group. a Tumor weight of PC3 xenografts treated or not with KPT-330. b Time to Progression (TTP) calculated in PC3 xenografts. c Hazard ratio values. d Determination of tumor weight in DU145 xenografts treated or not with KPT330. e Time to Progression (TTP) calculated in DU145 xenografts. f Hazard ratio values. g Determination of tumor weight in 22rv1 xenografts treated or not with KPT-330. h Time to Progression (TTP) calculated in 22rv1 xenografts. i Hazard ratio values

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