From: Understanding of BRCA VUS genetic results by breast cancer specialists
Total | Medical oncologist | Clinical oncologist | Surgeon | |
---|---|---|---|---|
No. (%) | No. (%) | No. (%) | No. (%) | |
155 (100 %) | 63 (40.7 %) | 54 (34.8 %) | 38 (24.5 %) | |
Interpretation of report 1 | ||||
No pathogenic mutation | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
A gene mutation found but unknown if causing her breast cancer | 130 (83.9 %) | 57 (90.5 %) | 45 (83.3 %) | 28 (73.7 %) |
A pathogenic BRCA2 gene mutation | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
Don’t know | 21 (13.6 %) | 5 (7.9 %) | 8 (14.8 %) | 8 (21.1 %) |
Other | 4 (2.6 %) | 1 (1.6 %) | 1 (1.9 %) | 2 (5.3 %) |
Communication to patient report 1a | ||||
Reassure the patient that there is no hereditary cause for her breast cancer. | 1 (0.6 %) | 0 (0 %) | 1 (1.9 %) | 0 (0 %) |
Explain there may be a hereditary cause and discuss further tests. | 95 (61.2 %) | 45 (71.4 %) | 29 (53.7 %) | 21 (55.3 %) |
Explain BRCA2 mutation contributed to causing her breast cancer. | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
Explain she has a BRCA2 mutation discuss risk reducing options. | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
Refer patients to a genetics consultant. | 81 (52.2 %) | 36 (57.1 %) | 30 (55.6 %) | 15 (39.5 %) |
Don't know. | 7 (4.5 %) | 0 (0 %) | 3 (5.6 %) | 4 (10.5 %) |
Other (free text) | 11 (7.1 %) | 4 (6.3 %) | 2 (3.7 %) | 5 (13.2 %) |
Interpretation of report 2 | ||||
No pathogenic mutation | 35 (22.6 %) | 18 (28.6 %) | 10 (18.5 %) | 7 (18.4 %) |
A gene mutation found but unknown if causing her breast cancer | 71 (45.8 %) | 31 (49.2 %) | 23 (42.6 %) | 17 (44.7 %) |
A pathogenic BRCA2 gene mutation | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
Don't Know | 49 (31.6 %) | 14 (22.2 %) | 21 (38.9 %) | 14 (36.8 %) |
Communication to patient report 2a | ||||
Reassure the patient that there is no hereditary cause for her breast cancer. | 10 (6.5 %) | 2 (3.2 %) | 2 (3.7 %) | 6 (15.8 %) |
Explain there may be a hereditary cause and discuss further tests. | 13 (8.4 %) | 7 (11.1 %) | 3 (5.6 %) | 3 (7.9 %) |
Explain BRCA2 mutation contributed to causing her breast cancer. | 1 (0.6 %) | 0 (0 %) | 1 (1.9 %) | 0 (0 %) |
Explain she has a BRCA2 mutation discuss risk reducing options. | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
Refer patients to a genetics consultant. | 68 (43.8 %) | 24 (38.1 %) | 24 (44.4 %) | 14 (36.8 %) |
Don't know/no answer | 58 (37.4 %) | 25 (39.7 %) | 22 (40.7 %) | 11 (28.9 %) |
Other (free text) | 12 (7.7 %) | 5 (7.9 %) | 2 (3.7 %) | 5 (13.2 %) |