Fig. 1

DOX and AD198 inhibited cell viability of human TCC cells. (a) Human urinary bladder transitional cell carcinoma (TCC) cells T24 and (b) UMUC3 cells were treated with Dox (black bars) and AD198 (white bars) at 0.1, 0.5, 1 and 5 μM for 48 h and compared to control groups. Cell proliferation was determined by MTS assay and relative cell growth rate was normalized to control counterpart. Values represent mean ± S.E. of four replicates from three independent experiments. Paired Student t-tests were used to compare Dox and AD198 treatment to control; * p ≤ 0.05 and *** p ≤ 0.001. Paired Student t-tests were used to compare among Dox and AD198 group at the same dose treatment; ^## p ≤ 0.01 and ^### p ≤ 0.001