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Table 1 Main characteristics of included studies

From: Aberrant GSTP1 promoter methylation is associated with increased risk and advanced stage of breast cancer: a meta-analysis of 19 case-control studies

Study ID

Ethnicity

Sample type

Case/ control

Methods (techniques)

GSTP1 (M/N)

Stage (M/N)

Grade (M/N)

Cacer

Normal

Early-stage

Late-stage

Low-grade

High-grade

Jeronimo 2003 [20]

Caucasian

Tissue

27/12

MSP (Non-quantitative)

17/27

0/12

-

-

-

-

Shinozaki 2005 [21]

Caucasian

Tissue

151/10

MSP (Non-quantitative)

32/151

0/10

-

-

-

-

Hoque 2006 [22]

African

Blood

90/38

QMSP (Quantitative)

12/47

0/38

6/24

22/66

-

-

Lee 2007 [23]

Asian

Tissue

85/15

MSP+ (Non-quantitative)

32/85

0/15

-

-

-

-

Pasquali 2007 [24]

Caucasian

Tissue

15/15

Pyrosequencing (Quantitative)

9/15

2/15

-

-

-

-

Jeronimo 2008 [25]

Caucasian

Tissue

66/12

QMSP (Quantitative)

33/66

2/12

-

-

-

-

Hoque 2009 [26]

Caucasian

Tissue

112/32

QMSP (Quantitative)

22/112

3/32

-

-

-

-

Brooks 2010 [27]

Mixed

Blood

50/99

QMSP (Quantitative)

2/50

7/99

-

-

-

-

Matuschek 2010 [28]

Caucasian

Blood

76/16

MethyLight assay (Quantitative)

14/76

1/16

3/39

9/31

-

-

Sharma 2010 [29]

Asian

Tissue

100/15

MSP (Non-quantitative)

25/100

1/15

8/51

17/49

15/48

8/28

Blood

100/30

22/100

1/30

6/51

16/49

13/48

8/28

Moelans 2011 [30]

Caucasian

Tissue

72/9

MS–MLPA (Semi-quantitative)

32/72

0/9

-

-

4/25

4/14

Park 2011 [31]

Asian

Tissue

85/30

MethyLight assay (Quantitative)

25/85

0/30

-

-

6/30

8/20

Kornegoor 2012 [32]

Caucasian

Tissue

108/10

MS–MLPA (Semi-quantitative)

47/108

0/10

-

-

-

-

Yamamoto 2012 [33]

Asian

Tissue

94/53

MSP+ (Non-quantitative)

45/94

1/53

26/56

19/38

-

-

Blood

159/87

21/159

2/87

3/68

9/57

-

-

Jung 2013 [34]

Asian

Tissue

60/60

MS–MLPA (Semi-quantitative)

10/60

2/60

10/53

0/7

6/40

4/20

Klajic 2013 [35]

Caucasian

Tissue

219/6

Pyrosequencing (Quantitative)

142/219

0/6

53/85

74/108

-

-

de Groot 2014 [36]

Caucasian

Tissue

21/10

Gel-based MSP (Semi-quantitative)

9/21

0/10

-

-

-

-

  1. MSP methylation-specific PCR, QMSP quantitative MSP, MS-MLPA methylation-specific multiplex ligation-dependent probe amplification, MSP+ based on MSP with slight modifications, M the number of methylations, N number of total
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BMC Cancer

ISSN: 1471-2407

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