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Table 1 Main characteristics of included studies

From: Aberrant GSTP1 promoter methylation is associated with increased risk and advanced stage of breast cancer: a meta-analysis of 19 case-control studies

Study ID Ethnicity Sample type Case/ control Methods (techniques) GSTP1 (M/N) Stage (M/N) Grade (M/N)
Cacer Normal Early-stage Late-stage Low-grade High-grade
Jeronimo 2003 [20] Caucasian Tissue 27/12 MSP (Non-quantitative) 17/27 0/12 - - - -
Shinozaki 2005 [21] Caucasian Tissue 151/10 MSP (Non-quantitative) 32/151 0/10 - - - -
Hoque 2006 [22] African Blood 90/38 QMSP (Quantitative) 12/47 0/38 6/24 22/66 - -
Lee 2007 [23] Asian Tissue 85/15 MSP+ (Non-quantitative) 32/85 0/15 - - - -
Pasquali 2007 [24] Caucasian Tissue 15/15 Pyrosequencing (Quantitative) 9/15 2/15 - - - -
Jeronimo 2008 [25] Caucasian Tissue 66/12 QMSP (Quantitative) 33/66 2/12 - - - -
Hoque 2009 [26] Caucasian Tissue 112/32 QMSP (Quantitative) 22/112 3/32 - - - -
Brooks 2010 [27] Mixed Blood 50/99 QMSP (Quantitative) 2/50 7/99 - - - -
Matuschek 2010 [28] Caucasian Blood 76/16 MethyLight assay (Quantitative) 14/76 1/16 3/39 9/31 - -
Sharma 2010 [29] Asian Tissue 100/15 MSP (Non-quantitative) 25/100 1/15 8/51 17/49 15/48 8/28
Blood 100/30 22/100 1/30 6/51 16/49 13/48 8/28
Moelans 2011 [30] Caucasian Tissue 72/9 MS–MLPA (Semi-quantitative) 32/72 0/9 - - 4/25 4/14
Park 2011 [31] Asian Tissue 85/30 MethyLight assay (Quantitative) 25/85 0/30 - - 6/30 8/20
Kornegoor 2012 [32] Caucasian Tissue 108/10 MS–MLPA (Semi-quantitative) 47/108 0/10 - - - -
Yamamoto 2012 [33] Asian Tissue 94/53 MSP+ (Non-quantitative) 45/94 1/53 26/56 19/38 - -
Blood 159/87 21/159 2/87 3/68 9/57 - -
Jung 2013 [34] Asian Tissue 60/60 MS–MLPA (Semi-quantitative) 10/60 2/60 10/53 0/7 6/40 4/20
Klajic 2013 [35] Caucasian Tissue 219/6 Pyrosequencing (Quantitative) 142/219 0/6 53/85 74/108 - -
de Groot 2014 [36] Caucasian Tissue 21/10 Gel-based MSP (Semi-quantitative) 9/21 0/10 - - - -
  1. MSP methylation-specific PCR, QMSP quantitative MSP, MS-MLPA methylation-specific multiplex ligation-dependent probe amplification, MSP+ based on MSP with slight modifications, M the number of methylations, N number of total
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