Fig. 4

Low dose bevacizumab treatment reduced K ^trans in A-07 tumors. K ^trans images and K ^trans frequency distributions recorded before treatment, and 3 and 7 days after the treatment started. The panels show a representative untreated A-07 tumor (a), a representative bevacizumab-treated A-07 tumor (b), a representative untreated R-18 tumor (c), and a representative bevacizumab-treated R-18 tumor (d). The images refer to the central axial section of the tumor, whereas the frequency distributions are based on the individual voxel values of all the sections of the tumor. Color bars show K ^trans scales, scale bars are 2 mm, and the vertical lines in the frequency distributions indicate median values