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Fig. 4 | BMC Cancer

Fig. 4

From: Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation

Fig. 4

Phosphorylation of MAPKs under diacerein treatment. a MAPKs phosphorylation of Cal-78 and SW-1353 chondrosarcoma cell lines in percent change after 30 μM diacerein for 24 h. b Western blot analysis confirmed the results of the proteome profiler phospho-MAPK array and showed a significant increase of phospho-Akt and phospho-p38 after the treatment with different concentrations of diacerein in SW-1353 cells, whereas, no significant changes can be observed in the Cal-78 cells. The expression of p53 was diminished in Cal-78 cells. c Relationship of interesting genes using IPA (Ingenuity Pathway Analysis)

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