TY - JOUR AU - Burke, K. AU - Smid, M. AU - Dawes, R. P. AU - Timmermans, M. A. AU - Salzman, P. AU - van Deurzen, C. H. M. AU - Beer, David G. AU - Foekens, J. A. AU - Brown, E. PY - 2015 DA - 2015/11/24 TI - Using second harmonic generation to predict patient outcome in solid tumors JO - BMC Cancer SP - 929 VL - 15 IS - 1 AB - Over-treatment of estrogen receptor positive (ER+), lymph node-negative (LNN) breast cancer patients with chemotherapy is a pressing clinical problem that can be addressed by improving techniques to predict tumor metastatic potential. Here we demonstrate that analysis of second harmonic generation (SHG) emission direction in primary tumor biopsies can provide prognostic information about the metastatic outcome of ER+, LNN breast cancer, as well as stage 1 colorectal adenocarcinoma. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-015-1911-8 DO - 10.1186/s12885-015-1911-8 ID - Burke2015 ER -