Low-dose aspirin and survival from lung cancer: a population-based cohort study

BMC Cancer

Table 4 Association between low-dose aspirin usage in the year prior to diagnosis and cancer-specific and all-cause mortality in lung cancer patients

Medication usage after diagnosis	Cancer-specific deaths	All-cause mortality	All patients	Person years	Cancer-specific mortality						All-cause mortality
Medication usage after diagnosis	Cancer-specific deaths	All-cause mortality	All patients	Person years	Unadjusted		P	Adjusted^a		P	Unadjusted		P	Adjusted^a		P
					HR	95 % CI		HR	95 % CI		HR	95 % CI		HR	95 % CI
Number of patients					[n = 13,433]			[n = 13,388]			[n = 13,433]			[n = 13,388]
Aspirin non-user	7,577	8,369	9,564	9,154	1.00	Referent		1.00	Referent		1.00	Referent		1.00	Referent
Aspirin user	3,055	3,468	3,869	3,331	1.07	1.02, 1.11	<0.01	1.00	0.95, 1.05	0.91	1.10	1.05, 1.14	<0.001	1.01	0.96, 1.06	0.77
Aspirin non-user	7,577	8,369	9,564	9,154	1.00	Referent		1.00	Referent		1.00	1.00		1.00	Referent
Aspirin user 1 to 11 prescriptions	2,367	2,690	2,998	2,608	1.06	1.01, 1.11	0.02	0.99	0.94, 1.04	0.75	1.09	1.04, 1.14	<0.001	1.00	0.95, 1.05	0.90
Aspirin user ≥ 12 prescriptions	688	778	871	723	1.09	1.01, 1.18	0.03	1.02	0.94, 1.11	0.64	1.11	1.04, 1.20	<0.01	1.02	0.95, 1.11	0.57
Aspirin non-user	7,577	8,369	9,564	9,154	1.00	Referent		1.00	Referent		1.00	1.00		1.00	Referent
Aspirin user 1–365 tablets	2,214	2,508	2,804	2,436	1.06	1.01, 1.12	0.01	1.00	0.95, 1.06	0.97	1.09	1.04, 1.14	<0.001	1.01	0.96, 1.06	0.70
Aspirin user ≥366 tablets	841	960	1,065	895	1.07	1.00, 1.15	0.06	0.98	0.91, 1.06	0.70	1.11	1.04, 1.18	<0.01	1.00	0.93, 1.07	0.97

^aAdjusted for year of diagnosis, age at diagnosis, gender, comorbidities (prior to diagnosis, including cerebrovascular disease, chronic pulmonary disease, congestive heart disease, diabetes, myocardial infarction, peptic ulcer disease, peripheral vascular disease, renal disease), other medication use (in year prior to diagnosis, specifically statins and beta-blockers) and deprivation (in fifths)

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