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Table 3 Sensitivity analyses for association between low-dose aspirin use and cancer-specific mortality in lung cancer patients

From: Low-dose aspirin and survival from lung cancer: a population-based cohort study

  Cancer-specific deaths All patients Person years User versus non-user User versus non-user  
Unadjusted P Adjusted HRa P P for interaction
     HRa 95 % CI   HRa 95 % CI   
Main analysis: Aspirin user versus non-user after diagnosis 2,247 3,635 6,745 0.96 0.87, 1.05 0.36 0.96 0.85, 1.09 0.55  
Sub group analyses: Aspirin user versus non-user after diagnosis, restricted to:         
 Males 1,312 2,105 3,750 1.00 0.89, 1.12 0.97 1.05 0.90, 1.22 0.54 0.12
 Females 935 1,530 2,995 0.87 0.75, 1.02 0.08 0.81 0.66, 0.99 0.05
 Pre-diagnosis aspirin non-usersb 1,515 2,446 4,578 0.89 0.74, 1.07 0.21 0.91 0.73, 1.14 0.42 0.48
 Pre-diagnosis aspirin usersb 554 908 1,601 0.92 0.72, 1.16 0.47 1.02 0.77, 1.35 0.90
 Small cell lung cancer 328 424 592 0.84 0.66, 1.09 0.19 0.72 0.52, 1.01 0.05 0.03
 Non-small cell lung cancer 1,523 2,615 5,355 0.95 0.85, 1.06 0.35 1.00 0.86, 1.16 0.99
 Surgically treated 305 872 2,714 0.99 0.78, 1.27 0.96 0.95 0.71,1.28 0.74 0.39
 Non-surgically treated 820 1,708 4,216 0.94 0.80, 1.10 0.42 0.89 0.74, 1.07 0.22
Sensitivity analyses: Aspirin user versus non-user after diagnosis         
 Increasing lag to 1 year 2,247 3,635 6,745 0.97 0.88, 1.07 0.56 0.97 0.85, 1.10 0.60  
 Excluding patients who died within the first 6 months after diagnosis 4,440 6,158 9,101 0.96 0.90, 1.03 0.28 0.95 0.87–1.04 0.30  
 Additionally adjusting for smoking prior to diagnosis 2037 3,315 6,074 0.95 0.86, 1.04 0.28 0.95 0.84, 1.08 0.41  
 Additionally adjusting for BMI prior to diagnosis 1,849 3,048 5,640 0.93 0.84, 1.03 0.15 0.95 0.84, 1.09 0.47  
 Additionally adjusting for small cell/non-small cell 1,851 3,039 5,947 0.92 0.83, 1.03 0.14 0.92 0.80, 1.05 0.23  
 Based upon first year after diagnosisc 1,728 2,791 5,223 0.93 0.87, 1.05 0.33 0.99 0.88, 1.13 0.91  
 Nested case–control analysisd,e 2,247    0.93 0.85, 1.03 0.19 1.00 0.86, 1.16 0.97  
  1. aExcept where otherwise stated, all analyses of post-diagnostic aspirin use adjusted for year of diagnosis, age at diagnosis, gender, surgery within 6 months of diagnosis, radiotherapy within 6 months, chemotherapy within 6 months, comorbidities (prior to diagnosis, including cerebrovascular disease, chronic pulmonary disease, congestive heart disease, diabetes, myocardial infarction, peptic ulcer disease, peripheral vascular disease, renal disease), other medication use (after diagnosis, as time varying covariates, specifically statins and beta-blockers) and deprivation (in fifths)
  2. bBased upon aspirin use in the year prior to diagnosis, restricted to individuals with 1 year of records prior to lung cancer diagnosis
  3. cSimplified analysis, not requiring time varying covariate use, comparing aspirin users to aspirin non-users in the first year after diagnosis in individuals living more than 1 year after cancer diagnosis, adjusted for all confounders ina but other medication use also restricted to first year after diagnosis
  4. dUnadjusted OR estimate and 95 % CIs based on 28 % (623/2,247) of cancer-specific deaths using aspirin compared with 31 % (3,254/10,603) of risk-set controls (not dying from cancer)
  5. eAdjusted OR estimate and 95%CIs, matched on age at diagnosis, year of diagnosis, gender and adjusted for all other confounders ina