|  |  |  | Patient age (years) |  |  | Follow-up (years) | ||
---|---|---|---|---|---|---|---|---|---|
Study and publication year | Collection of patient data | Study design | Country | Mean or median | Range | Diagnosed at ≤ 40 years (%) | Number of eligible cases (Adjusted)a | Mean or median | Adjusteda |
Betsill-1978 [32] | 1940–1950 | R | US | 48.2 | 34–59 | 20c | 8 | 18f | 10 |
Millis-1975 [19] | 1948–1968 | R | UK | 47 | 39–79 | 20 | 16 | >15 | 10 |
Sanders-2005 [29] | 1950–1968 | R | US | 52b | 33–80 | 25 | 25 | 31 | 10 |
Wanebo-1974 [23] | 1953–1972 | R | US | 53 | 22–86 | NR | 14 | ≥10 | 10 |
Sunshine-1985 [17] | 1960–1972 | R | US | ABO | NR | 28d | 85 | >10 | >10 |
Akashi-Tanaka-2000 [20] | 1962–1995 | R | JP | 47b | 19–92 | NR | 13 | 13.4 | 10 |
Eusebi-1994 [30] | 1964–1976 | R | IT | 48.6 | 24–77 | 24 | 71 | 17.5f | 10 |
Simpson-1992 [22] | 1967–1977 | R | US | NR | NR | NR | 30 | 17.7f | 10 |
Solin-1996 [27] | 1967–1985 | R | EU/US | 50 | 26–82 | NR | 270 | 10.3 | 10.3 |
Lagios-1989 [24] | 1972–1980 | R | US | 54 | 16–85 | NR | 20 | 10.3 | 10.3 |
Collins-2005 [31] | 1973–1991 | R | US | 55 | 39–63 | 7.7 | 13 | 17.4f | 10 |
Lara-2003 [21] | 1974–1992 | R | US | 56 | 31–82 | NR | 73 | 19f | 10 |
Tunon-de-Lara-2010 [18] | 1974–2003 | R | FR | 36.3 | 18–40 | 100 | 207 | 13.3 | 13.3 |
Di Saverio-2008 [25] | 1976–2006 | R | IT | ABO | NR | 8.5 | 186 | 10.8f | 10.8 |
Ward-1992 [28] | 1979–1983 | R | US | 58.4b | NR | NR | 11 | >10f | 10 |
Shaitelman-2012 [33] | 1980–1993 | R | US | NR | NR | 20.7 | 145 | 19.3 | 10 |
Ottesen-2000 [13] | 1982–1989 | P | DK | 48^ | 29–85 | NR | 168 | 10 | 10 |
Holmes-2011 [34] | 1983–2002 | R | US | 55.5 | NR | 34e | 141 | 10.2 | 10.2 |
Fisher-2001 [9] (B-17) | 1985–1990 | P + RCT | US | ABO | NR | NR | 813 | 10.8 | 10.8 |
Vidali-2012 [16] | 1985–2000 | R | IT | 55 | 29–84 | 5.5 | 586 | 11.3 | 11.3 |
Bijker-2006 [10] | 1986–1996 | P + RCT | EU | 53 | 25–76 | 6.4 | 1010 | 10.5 | 10.5 |
Cuzick-2011 [11] | 1990–1998 | P + RCT | UK/ANZ | ABO | NR | 3.3d | 1694 | 12.7 | 12.7 |
Owen-2013 [14] | 1990–1999 | P + R | CA | 55 | 27–92 | 8.6 | 637 | 12 | 12 |
Wapnir-2011 [12] (B-24) | 1991–1994 | P + RCT | US | 55 | NR | 17.3 | 1184 | 13.6 | 10 |
Rudloff-2009 [26] | 1991–1995 | R | US | 55 | 26–89 | 15.6d | 91 | 11 | 11 |
Rakovitch-2013 [15] | 1994–2003 | R | CA | 56 | 20–85 | 12.4 | 1893 | 10 | 10 |