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Table 1 Characteristics of eligible studies and patients (n = 9404) in ductal carcinoma in situ meta-analysis

From: Long-term outcomes of ductal carcinoma in situ of the breast: a systematic review, meta-analysis and meta-regression analysis

    

Patient age (years)

  

Follow-up (years)

Study and publication year

Collection of patient data

Study design

Country

Mean or median

Range

Diagnosed at ≤ 40 years (%)

Number of eligible cases (Adjusted)a

Mean or median

Adjusteda

Betsill-1978 [32]

1940–1950

R

US

48.2

34–59

20c

8

18f

10

Millis-1975 [19]

1948–1968

R

UK

47

39–79

20

16

>15

10

Sanders-2005 [29]

1950–1968

R

US

52b

33–80

25

25

31

10

Wanebo-1974 [23]

1953–1972

R

US

53

22–86

NR

14

≥10

10

Sunshine-1985 [17]

1960–1972

R

US

ABO

NR

28d

85

>10

>10

Akashi-Tanaka-2000 [20]

1962–1995

R

JP

47b

19–92

NR

13

13.4

10

Eusebi-1994 [30]

1964–1976

R

IT

48.6

24–77

24

71

17.5f

10

Simpson-1992 [22]

1967–1977

R

US

NR

NR

NR

30

17.7f

10

Solin-1996 [27]

1967–1985

R

EU/US

50

26–82

NR

270

10.3

10.3

Lagios-1989 [24]

1972–1980

R

US

54

16–85

NR

20

10.3

10.3

Collins-2005 [31]

1973–1991

R

US

55

39–63

7.7

13

17.4f

10

Lara-2003 [21]

1974–1992

R

US

56

31–82

NR

73

19f

10

Tunon-de-Lara-2010 [18]

1974–2003

R

FR

36.3

18–40

100

207

13.3

13.3

Di Saverio-2008 [25]

1976–2006

R

IT

ABO

NR

8.5

186

10.8f

10.8

Ward-1992 [28]

1979–1983

R

US

58.4b

NR

NR

11

>10f

10

Shaitelman-2012 [33]

1980–1993

R

US

NR

NR

20.7

145

19.3

10

Ottesen-2000 [13]

1982–1989

P

DK

48^

29–85

NR

168

10

10

Holmes-2011 [34]

1983–2002

R

US

55.5

NR

34e

141

10.2

10.2

Fisher-2001 [9] (B-17)

1985–1990

P + RCT

US

ABO

NR

NR

813

10.8

10.8

Vidali-2012 [16]

1985–2000

R

IT

55

29–84

5.5

586

11.3

11.3

Bijker-2006 [10]

1986–1996

P + RCT

EU

53

25–76

6.4

1010

10.5

10.5

Cuzick-2011 [11]

1990–1998

P + RCT

UK/ANZ

ABO

NR

3.3d

1694

12.7

12.7

Owen-2013 [14]

1990–1999

P + R

CA

55

27–92

8.6

637

12

12

Wapnir-2011 [12] (B-24)

1991–1994

P + RCT

US

55

NR

17.3

1184

13.6

10

Rudloff-2009 [26]

1991–1995

R

US

55

26–89

15.6d

91

11

11

Rakovitch-2013 [15]

1994–2003

R

CA

56

20–85

12.4

1893

10

10

  1. Abbreviations: R retrospective, P prospective, RCT randomized controlled trial, US United States, CA Canada, UK United Kingdom, JP Japan, IT Italy, EU Europe, FR France, DK Denmark, ANZ Australia and New Zealand, ABO age bands only, NR not reported
  2. aAs close as possible to 10 years from ≥10-year eligible data
  3. bfor the DCIS patients in study
  4. cIncluded all patients in study
  5. d < 45 years
  6. e < 50 years
  7. fmean