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Table 3 Individual and joint effects of smoking and drinking on NPC adjusted for age, sex, education, cohort & occupational status

From: Smoking and nasopharyngeal carcinoma mortality: a cohort study of 101,823 adults in Guangzhou, China

Category

Total person-years of participants

Mortality rate of NPC per 10,000 person-years (95 % CI)

No of deaths

Model 2 HR (95 % CI)

Smoking and drinking status

 Never smoker and never drinker

390,148

0.21 (0.10–0.41)

8

1.00

 Never smoker and daily drinker

6265

1.60 (0.22–11.33)

1

4.19 (0.47–37.22)

 Daily smoker and never drinker

240,998

0.50 (0.28–0.88)

12

2.95 (1.01–8.68)*

 Daily smoker and daily drinker

56,597

1.06 (0.48–2.36)

6

3.38 (0.95–11.97)

Smoking amount and drinking status (cigarettes/day)a

 Never smoker and never drinker

390,148

0.21 (0.10–0.41)

8

1.00

 Never smoker and daily drinker

6265

1.60 (0.22–11.33)

1

4.49 (0.51–39.90)

 Level 1 smoking amount and never drinker

125,001

0.32 (0.12–0.85)

4

2.15 (0.56–8.18)

 Level 1 smoking amount and daily drinker

21,113

/

0

/

 Level 2 smoking amount and never drinker

115,997

0.53 (0.28–1.02)

8

3.55 (1.12–11.31)*

 Level 2 smoking amount and daily drinker

35,485

1.28 (0.58–2.86)

6

4.86 (1.34–17.61)*

Smoking duration and drinking status (years)b

 Never smoker and never drinker

390,148

0.21 (0.10–0.41)

8

1.00

 Never smoker and daily drinker

6265

1.60 (0.22–11.33)

1

4.21 (0.47–37.41)

 Level 1 smoking duration and never drinker

71,958

0.42 (0.13–1.29)

3

3.52 (0.81–15.34)

 Level 1 smoking duration and daily drinker

9877

/

0

/

 Level 2 smoking duration and never drinker

169,040

0.53 (0.28–1.02)

9

2.67 (0.87–8.23)

 Level 2 smoking duration and daily drinker

46,720

1.28 (0.58–2.86)

6

3.61 (1.01–12.93)*

Smoking cumulative consumption and drinking status (pack-years)c

 Never smoker and never drinker

390,148

0.21 (0.10–0.41)

8

1.00

 Never smoker and daily drinker

6265

1.60 (0.22–11.33)

1

4.65 (0.52–41.41)

 Level 1 smoking cumulative consumption and never drinker

143,711

0.28 (0.10–0.74)

4

2.10 (0.55–8.11)

 Level 1 smoking cumulative consumption and daily drinker

22,306

/

0

/

 Level 2 smoking cumulative consumption and never drinker

97,286

0.82 (0.41–1.64)

8

3.69 (1.15–11.82)*

 Level 2 smoking cumulative consumption and daily drinker

34,291

1.75 (0.79–3.89)

6

4.77 (1.30–17.50)*

  1. Model 2 – adjusted for age, sex, education, cohort & occupational status with smoking and alcohol interaction terms
  2. *p < 0.05
  3. aLevel 1: smoked 1–14 cigarettes per day, Level 2: smoked more than 15 cigarettes per day
  4. bLevel 1: 1–9 years of smoking duration, Level 2: more than 10 years of smoking duration
  5. cLevel 1: less than 10 pack-years of smoking cumulative consumption, Level 2: more than 10 pack-years of smoking cumulative consumption