Fig. 7
From: Chemopreventive effect of chalcone derivative, L2H17, in colon cancer development
Treatment of L2H17 inhibited the tumorigenesis of CT26.WT cells in BALB/c mice. CT26.WT cells were harvested and injected intravenously into the BALB/c mice (3 × 105 cells/mouse). Simultaneously, the mice were administered orally with either L2H17 (25 mg/kg/day or 50 mg/kg/day), curcumin (50 mg/kg/day, 100 mg/kg/day) or vehicle control (1 % CMC-Na) for 60 days, while the tumor-free control mice were treated with the L2H17 (50 mg/kg/day), curcumin (100 mg/kg/day), or 1 % CMC-Na as the negative control (n = 9 in each group). Shown are survival (a) and body weight change (b). The indicated differences are significant *P <0.05 and **P < 0.01, log-rank test, compared to the CT26.WT + CMC-Na-treated group