Fig. 1

Chalcone derivatives reduced viability of colon cancer cells. (a) Structures of curcumin and chalcone derivatives. Colon cancer cell lines, such as SW620 (b), HCT116 (c), CT26.WT (d), and human hepatocytes HL-7702 cells (e) were treated with chalcone derivatives (L2H17, L40H37, L6H21, or L48H37) or curcumin at various concentrations (1, 3, 10, 30, or 100 μM) for 48 h, while DMSO was used as the vehicle control. After 48-h treatment, the cell proliferation of each group was assessed by MTT assay. The data were obtained from three independent experiments performed in triplicate, and the results were expressed as percentage of vehicle (DMSO) control. The data were presented as mean ± SEMs, and fitted with GraphPad Prism 5.0 to obtain the IC₅₀ values