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Table 2 Alcohol intake and risk of breast cancer by hormone receptor status in the Swedish Women’s Lifestyle and Health study

From: Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

Alcohol intake (g/day)

Total

0

0.1–5

5.1–15

>15

Per 5 g/day increase

No. of participants

45,233

10,153

22,249

11,734

1,097

 

Person-year

758,430

151,813

354,589

221,531

30,497

 

Total breast cancer (No.)

1,385

276

646

421

42

 

RR (95 % CI)- unadjusted

 

1.0

1.07 (0.92–1.25)

1.24 (1.06–1.45)

1.29 (0.99–1.67)

1.02 (1.00–1.04)

RR (95 % CI)- adjusted

 

1.0

1.03 (0.89–1.20)

1.16 (0.99–1.36)

1.17 (0.90–1.53)

1.01 (0.98–1.04)

ER(+)/PR(+) breast cancer (No.)

718

140

353

205

19

 

RR (95 % CI)- unadjusted

 

1.0

1.17 (0.95–1.46)

1.25 (1.00–1.56)

1.21 (0.83–1.77)

1.02 (0.98–1.05)

RR (95 % CI)- adjusted

 

1.0

1.13 (0.91–1.40)

1.17 (0.93–1.47)

1.11 (0.76–1.63)

1.01 (0.97–1.05)

ER(+)/PR(−) breast cancer (No.)

196

39

88

65

4

 

RR (95 % CI)- unadjusted

 

1.0

0.99 (0.66–1.50)

1.31 (0.87–1.99)

1.04 (0.51–2.15)

1.01 (0.95–1.08)

RR (95 % CI)- adjusted

 

1.0

1.00 (0.66–1.51)

1.35 (0.89–2.06)

1.09 (0.53–2.25)

1.02 (0.95–1.08)

ER(−)/PR(−) breast cancer (No.)

187

45

83

51

8

 

RR (95 % CI)- unadjusted

 

1.0

0.95 (0.64–1.42)

1.03 (0.67–1.57)

1.27 (0.64–2.52)

1.01 (0.92–1.10)

RR (95 % CI)- adjusted

 

1.0

0.90 (0.60–1.33)

0.91 (0.59–1.39)

1.04 (0.52–2.08)

0.98 (0.87–1.33)

  1. Adjusted models were adjusted for educational attainment (0–11 years/>11 years), history of breast cancer in mother and/or sister (Yes/No), smoking habits (current/former/never smokers), age at menarche (years), parity at baseline (0, 1, 2, 3, and >3), age at the first child birth (years), total breast feeding duration (months), and oral contraceptive use (current/former/never)
  2. RR relative risk, CI confidence interval, ER estrogen receptor, PR progesterone receptor