Table 4 Adverse events

Sirolimus (n = 23)

   At least 1 toxicity reported

14 (60)

   Intestinal toxicity

8 (34)

7

1

   Skin toxicity, infections

1 (4)

1

1

   Hematologic toxicity

6 (26)

1

1

4

   Urinary toxicity

1 (4)

1

   Neurological toxicity

3 (13)

2

1

   Other (fatigue, pain)

6 (26)

4

2

   Dose modification

2 (9)

   Discontinuation for toxicity

1 (4)

Sunitinib (n = 5)

   At least 1 toxicity reported

4 (80)

   Hematologic toxicity

2 (40)

2

   Pulmonary toxicity

1 (20)

1

   Other (fatigue)

2 (40)

2

1

   Dose modification

1 (20)

Sorafenib (n = 4)

   At least 1 toxicity reported

3 (75)

   Skin toxicity, infections

2 (50)

1

1

   other (fatigue, psychological)

4 (100)

1

2

   Dose modification

2 (50)

Pazopanib (n = 1)

   At least 1 toxicity reported

1

   Intestinal toxicity

1

1

   Other (fatigue)

1

1

   Dose modification

0

Total

≥1 AE: 22

17

11

11