Fig. 5
From: Primary myeloma interaction and growth in coculture with healthy donor hematopoietic bone marrow
Coculture of MM cells in NBM system induces secretion of factors associated with modification of extracellular matrix and immune response. a Changes in cytokine (IL-6, IL-10, TGFβ-1) levels in conditioned media from 7-day coculture of three patients’ MM cells with NBM. Levels are shown as fold-increase of culture system without MM cells (BM). b Proteomics analyses identified factors in NBM/MM coculture supernatant (increased or decreased levels; p < 0.05; n = 3) compared to supernatant samples of BM cultured without MM cells or MM cells cultured alone. A thorough list is included in Additional file 4: Table S2