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Table 3 Effect of peptide 1 on malignant behaviors of ovarian cancer xenografts in nude mice

From: Phage display screening identifies a novel peptide to suppress ovarian cancer cells in vitro and in vivo in mouse models

Group

TFN

MTF

MR (%)

TV (ml)

TW (g)

IR (%)

Blank

7 (7/7)

103 ± 26.40

100

1.40 ± 0.64

1.77 ± 0.44

_

Control

7 (7/7)

94.86 ± 30.62

100

1.32 ± 0.75

1.67 ± 0.37

5.65

Peptide 1

7 (5/7)

28.60 ± 13.16*

71.4*

0.24 ± 0.18#

0.52 ± 0.28*

70.62

  1. TFN tumor formation number, MTF metastatic tumor foci, MR metastatic rate, TV tumor volume, TW tumor weight, IR inhibitory rate; The values of metastatic tumor foci and tumor weight are presented as mean ± SD of n = 7 mice in relevant groups. *P < 0.001 and # p < 0.05 vs. the control and HO8910 groups
  2. TFN, Five weeks post-inoculation, the nude mice were sacrificed, and then tumor formation was calculated for each mouse
  3. MTF, collection of all tumors in each mouse, and then measurements of the number of tumors
  4. MR, the MR of control = the MIF of control/ the MIF of blank; the MR of Peptide 1 = the MIF of Peptide 1 /the MIF of blank;
  5. TW, collect all the tumors from each mouse, and then their weights by scale
  6. IR, IR of control = [1-(the weight of control/the weight of blank)] *100 %
  7. IR of Peptide 1 = [1-(the weight of Peptide 1/the weight of blank)] *100 %