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Table 2 Correlation of EZH2 rs3757441 variants with EZH2/H3K27me3 expression

From: Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer

  EZH2 H3K27me3
  3+ staining intensity   % positive cells   SI 4–9   3+ staining intensity   % positive cells  
Genotype (n) n (%) P mean (SD) P n (%) P n (%) P mean (SD) P
C/C (5) 5 (100%)   60.0 (15.8)   5 (100%)   5 (100%)   82.0% (4.472)  
C/T (51) 20 (39%)   46.0 (27.7)   38 (74%)   18 (35%)   60.0% (30.53)  
T/T (63) 30 (48%) 0.028 46.0 (30.3) 0.571 44 (70%) 0.328 25 (40%) 0.022 66.19% (28.54) 0.200
C/C (5) 5 (100%)   60.0% (15.8)   5 (100%)   5 (100%)   82.0% (4.472)  
C/T or T/T (114) 50 (44%) 0.019 46.0% (29.1) 0.288 82 (72%) 0.322 43 (38%) 0.009 63.42% (29.47) 0.163
  1. Abbreviations: %, percentage; n, number; P, P-value; SD, standard deviation; SI, Staining Index
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BMC Cancer

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