Table 2 Correlation of EZH2 rs3757441 variants with EZH2/H3K27me3 expression
EZH2 | H3K27me3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
3+ staining intensity | % positive cells | SI 4–9 | 3+ staining intensity | % positive cells | ||||||
Genotype (n) | n (%) | P | mean (SD) | P | n (%) | P | n (%) | P | mean (SD) | P |
C/C (5) | 5 (100%) | 60.0 (15.8) | 5 (100%) | 5 (100%) | 82.0% (4.472) | |||||
C/T (51) | 20 (39%) | 46.0 (27.7) | 38 (74%) | 18 (35%) | 60.0% (30.53) | |||||
T/T (63) | 30 (48%) | 0.028 | 46.0 (30.3) | 0.571 | 44 (70%) | 0.328 | 25 (40%) | 0.022 | 66.19% (28.54) | 0.200 |
C/C (5) | 5 (100%) | 60.0% (15.8) | 5 (100%) | 5 (100%) | 82.0% (4.472) | |||||
C/T or T/T (114) | 50 (44%) | 0.019 | 46.0% (29.1) | 0.288 | 82 (72%) | 0.322 | 43 (38%) | 0.009 | 63.42% (29.47) | 0.163 |