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Table 3 Univariate and multivariate analyses of factors associated with the sites of recurrence

From: Prognostic significance of classified extramural tumor deposits and extracapsular lymph node invasion in T3–4 colorectal cancer: a retrospective single-center study

  Colon Rectum
  Liver Lung Distant LN Liver Lung Distant LN
  P P P P P P
Factor Uni Multi Uni Multi Uni Multi Uni Multi Uni Multi Uni Multi
Age (years): ≥70 0.55 0.20 0.054 0.15 0.057 0.74 0.64
Gender: Male 0.27 0.10 0.025 0.041 0.41 0.94 0.70
CEA (ng/ml): >5 0.14 0.26 0.54 0.78 0.59 0.75
pT: 4 0.016 0.88 0.51 0.0097 0.76 0.65 0.93 0.092 0.32
Tumor size (cm): <5 0.88 0.58 0.60 0.099 0.02 0.14 0.11
Histology: well/moderate 0.46 0.29 0.72 0.63 0.75 0.51
pN: (+) 0.0003 0.70 0.057 0.51 0.0006 0.64 0.023 0.22 0.0003 0.078 0.0097 0.55
Total LNs count: <12 0.41 0.17 0.43 0.099 0.064 0.16 0.36
LN ratio: ≥0.29 0.0013 0.99 0.098 0.49 0.0002 0.92 0.076 <0.0001 0.20 0.0041 0.44
Lymphatic invasion: (+) 0.033 0.37 0.50 0.28 0.13 0.023 0.48 0.015 0.13
Venous invasion: (+) 0.029 0.37 0.090 0.18 0.065 0.49 0.84 0.28 0.066 0,28
Chemotherapy: (−) 0.11 0.46 0.0003 0.18 0.82 0.30 0.083 0.29
iTD: (+) <0.0001 0.013 0.80 <0.0001 0.0055 0.011 0.0032 0.0008 0.27 0.029 0.59
nTD: (+) <0.0001 0.010 0.50 0.0026 0.15 0.70 0.12 0.94
ECLNI: (+) 0.0004 0.22 0.04 0.27 <0.0001 0.078 0.027 0.20 0.03 0.45 0.022 0.16
  1. RFS relapse-free survival, DSS disease-specific survival, CI confidence interval, CEA carcinoembryonic antigen, LN lymph node, iTD invasive-type tumor deposits, nTD nodular-type tumor deposits, ECLNI extracapsular lymph node involvement. Uni univariate analysis, Multi multivariate analysis
  2. Bold text indicates statistically significant P-values (<0.05). Underlined text indicates factors that were statistically significant in multivariate analysis