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Table 3 Univariate and multivariate analyses of factors associated with the sites of recurrence

From: Prognostic significance of classified extramural tumor deposits and extracapsular lymph node invasion in T3–4 colorectal cancer: a retrospective single-center study

 

Colon

Rectum

 

Liver

Lung

Distant LN

Liver

Lung

Distant LN

 

P

P

P

P

P

P

Factor

Uni

Multi

Uni

Multi

Uni

Multi

Uni

Multi

Uni

Multi

Uni

Multi

Age (years): ≥70

0.55

0.20

0.054

0.15

0.057

0.74

0.64

Gender: Male

0.27

0.10

0.025

0.041

0.41

0.94

0.70

CEA (ng/ml): >5

0.14

0.26

0.54

0.78

0.59

0.75

pT: 4

0.016

0.88

0.51

0.0097

0.76

0.65

0.93

0.092

0.32

Tumor size (cm): <5

0.88

0.58

0.60

0.099

0.02

0.14

0.11

Histology: well/moderate

0.46

0.29

0.72

0.63

0.75

0.51

pN: (+)

0.0003

0.70

0.057

0.51

0.0006

0.64

0.023

0.22

0.0003

0.078

0.0097

0.55

Total LNs count: <12

0.41

0.17

0.43

0.099

0.064

0.16

0.36

LN ratio: ≥0.29

0.0013

0.99

0.098

0.49

0.0002

0.92

0.076

<0.0001

0.20

0.0041

0.44

Lymphatic invasion: (+)

0.033

0.37

0.50

0.28

0.13

0.023

0.48

0.015

0.13

Venous invasion: (+)

0.029

0.37

0.090

0.18

0.065

0.49

0.84

0.28

0.066

0,28

Chemotherapy: (−)

0.11

0.46

0.0003

0.18

0.82

0.30

0.083

0.29

iTD: (+)

<0.0001

0.013

0.80

<0.0001

0.0055

0.011

0.0032

0.0008

0.27

0.029

0.59

nTD: (+)

<0.0001

0.010

0.50

0.0026

0.15

0.70

0.12

0.94

ECLNI: (+)

0.0004

0.22

0.04

0.27

<0.0001

0.078

0.027

0.20

0.03

0.45

0.022

0.16

  1. RFS relapse-free survival, DSS disease-specific survival, CI confidence interval, CEA carcinoembryonic antigen, LN lymph node, iTD invasive-type tumor deposits, nTD nodular-type tumor deposits, ECLNI extracapsular lymph node involvement. Uni univariate analysis, Multi multivariate analysis
  2. Bold text indicates statistically significant P-values (<0.05). Underlined text indicates factors that were statistically significant in multivariate analysis