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Table 1 Associations between iTD, nTD, and ECLNI status and various clinicopathological features

From: Prognostic significance of classified extramural tumor deposits and extracapsular lymph node invasion in T3–4 colorectal cancer: a retrospective single-center study

  iTD nTD ECLNI
Features (+) (n = 60) (−) (n = 325) P-value (+) (n = 45) (−) (n = 340) P-value (+) (n = 60) (−) (n = 119) P-value
Age (years)          
  Mean 67.1 67.7 0.67 65.6 67.9 0.19 68.3 66.2 0.22
  Range 26–89 33–91   26–89 33–91   48–89 26–88  
   ≥ 70 27 150 0.89 18 159 0.43 25 54 0.75
   < 70 33 175   27 181   35 65  
Gender    0.26    0.75    0.75
  Male 39 183   25 197   34 64  
  Female 21 142   20 143   26 55
CEA (ng/ml)    0.56    0.75    0.50
  >5 22 127   20 129   26 44  
  ≤5 34 164   24 174   29 64
Tumor site    0.20    0.0028    0.036
  Colon 41 248   25 264   49 78  
  Rectum 19 77   20 76   11 41
Tumor size (cm)    0.82    1.0    1.0
  <5 27 144   20 151   29 57
  ≥5 33 181   25 189   31 62
Histology    1.0    0.26    1.0
  Well/moderate 55 296   39 312   54 106
  Others 5 29   6 28   6 13
pT    0.0050    0.027    0.02
  3 43 284   33 294   41 100
  4 17 41   12 46   19 19
LNs (n)    0.65    0.17    0.49
  ≥12 40 226   27 239   45 82
  <12 20 99   18 101   15 37
pN    <0.0001    <0.0001    <0.0001
  0 5 201   6 200  
  1 28 97   21 104   30 95
  2 27 27   18 36   30 24
LN ratio    <0.0001    <0.0001    0.0027
  ≥0.29 26 17   17 26   23 20
  <0.29 34 308   28 314   37 99
Lymphatic invasion    0.0015    0.039    0.49
  (+) 53 230   39 244   49 99
  (−) 5 87   5 87   10 14
Venous invasion    0.026    0.0069    0.27
  (+) 55 263   43 275   56 100
  (−) 3 53   1 55 3 13
Stage    <0.0001    <0.0001    
  II 5 201   6 200    
  III 55 124   39 140   60 119
Chemotherapy    0.003    0.0008    0.033
  (+) 42 159   34 167   50 81
  (−) 18 166   11 173   10 38
Recurrence    <0.0001    <0.0001    0.032
  (−) 29 273   23 279   32 87  
  (+) Ma 3 23   8 18   8 9 1.0
  (+) Mb 28 29 0.0012 14 43 0.60 20 23
Cancer-specific death    0.0001    0.26    1.0
  (+) 10 10   4 15   5 9
  (−) 50 315   41 325   55 110
nTD    <0.0001       0.34
  (+) 21 24    16 23
  (−) 39 301    44 96
ECLNI    <0.0001    0.0003    
  (+) 25 35   16 44  
  (−) 35 290   29 296  
iTD       <0.0001    0.027
  (+)   21 39   25 32
  (−)   24 301   35 87
  1. iTD invasive-type tumor deposits, nTD nodular-type tumor deposits, ECLNI extracapsular lymph node involvement, CEA carcinoembryonic antigen, LN lymph node
  2. Bold text indicates statistically significant P-values (<0.05)