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Table 1 Associations between iTD, nTD, and ECLNI status and various clinicopathological features

From: Prognostic significance of classified extramural tumor deposits and extracapsular lymph node invasion in T3–4 colorectal cancer: a retrospective single-center study

 

iTD

nTD

ECLNI

Features

(+) (n = 60)

(−) (n = 325)

P-value

(+) (n = 45)

(−) (n = 340)

P-value

(+) (n = 60)

(−) (n = 119)

P-value

Age (years)

         

  Mean

67.1

67.7

0.67

65.6

67.9

0.19

68.3

66.2

0.22

  Range

26–89

33–91

 

26–89

33–91

 

48–89

26–88

 

   ≥ 70

27

150

0.89

18

159

0.43

25

54

0.75

   < 70

33

175

 

27

181

 

35

65

 

Gender

  

0.26

  

0.75

  

0.75

  Male

39

183

 

25

197

 

34

64

 

  Female

21

142

 

20

143

 

26

55

CEA (ng/ml)

  

0.56

  

0.75

  

0.50

  >5

22

127

 

20

129

 

26

44

 

  ≤5

34

164

 

24

174

 

29

64

Tumor site

  

0.20

  

0.0028

  

0.036

  Colon

41

248

 

25

264

 

49

78

 

  Rectum

19

77

 

20

76

 

11

41

Tumor size (cm)

  

0.82

  

1.0

  

1.0

  <5

27

144

 

20

151

 

29

57

  ≥5

33

181

 

25

189

 

31

62

Histology

  

1.0

  

0.26

  

1.0

  Well/moderate

55

296

 

39

312

 

54

106

  Others

5

29

 

6

28

 

6

13

pT

  

0.0050

  

0.027

  

0.02

  3

43

284

 

33

294

 

41

100

  4

17

41

 

12

46

 

19

19

LNs (n)

  

0.65

  

0.17

  

0.49

  ≥12

40

226

 

27

239

 

45

82

  <12

20

99

 

18

101

 

15

37

pN

  

<0.0001

  

<0.0001

  

<0.0001

  0

5

201

 

6

200

 

–

–

  1

28

97

 

21

104

 

30

95

  2

27

27

 

18

36

 

30

24

LN ratio

  

<0.0001

  

<0.0001

  

0.0027

  ≥0.29

26

17

 

17

26

 

23

20

  <0.29

34

308

 

28

314

 

37

99

Lymphatic invasion

  

0.0015

  

0.039

  

0.49

  (+)

53

230

 

39

244

 

49

99

  (−)

5

87

 

5

87

 

10

14

Venous invasion

  

0.026

  

0.0069

  

0.27

  (+)

55

263

 

43

275

 

56

100

  (−)

3

53

 

1

55

3

13

Stage

  

<0.0001

  

<0.0001

   

  II

5

201

 

6

200

   

  III

55

124

 

39

140

 

60

119

Chemotherapy

  

0.003

  

0.0008

  

0.033

  (+)

42

159

 

34

167

 

50

81

  (−)

18

166

 

11

173

 

10

38

Recurrence

  

<0.0001

  

<0.0001

  

0.032

  (−)

29

273

 

23

279

 

32

87

 

  (+) Ma

3

23

 

8

18

 

8

9

1.0

  (+) Mb

28

29

0.0012

14

43

0.60

20

23

Cancer-specific death

  

0.0001

  

0.26

  

1.0

  (+)

10

10

 

4

15

 

5

9

  (−)

50

315

 

41

325

 

55

110

nTD

  

<0.0001

     

0.34

  (+)

21

24

 

–

–

 

16

23

  (−)

39

301

 

–

–

 

44

96

ECLNI

  

<0.0001

  

0.0003

   

  (+)

25

35

 

16

44

 

–

–

  (−)

35

290

 

29

296

 

–

–

iTD

     

<0.0001

  

0.027

  (+)

–

–

 

21

39

 

25

32

  (−)

–

–

 

24

301

 

35

87

  1. iTD invasive-type tumor deposits, nTD nodular-type tumor deposits, ECLNI extracapsular lymph node involvement, CEA carcinoembryonic antigen, LN lymph node
  2. Bold text indicates statistically significant P-values (<0.05)
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BMC Cancer

ISSN: 1471-2407

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