Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

Table 1 Molecular pathology of the murine sarcomas

Mouse # (M/F)	Age (months)	S100	Cytokeratin	SMA	Desmin	Calponin	p53
1 (M)	9	0	0	3+	2+	focal-1+	3+
2 (M)	10	0	rare 2+	3+	2+	3+	0
3 (M)	8	0	rare 2+	3+	3+	0	1+
4 (M)	10	Rare nuclei	rare 1+	3+	2+	2+	1+
5 (M)	9	0	0	3+	3	focal-1+	0
6 (F)	7	0	0	2+	0	NA^*	0
7 (F)	9	0	0	3+	rare 2+	3+	3+
8 (M)	10	0	0	2+	1+	focal-1+	3+
9 (F)	10	0	0	2+	3+	0	0
10 (M)	9	0	rare 1+	2+	3+	2+	2+
11 (M)	8	0	0	3+	3+	2+	1+
12 (M)	2	0	0	1+	1+	focal-2+	0
13 (M)	9	0	0	2+	2+	focal-1+	3+
KHC-1	N/A	0	0	3+	2+	focal-2+	×
KHC-1	N/A	0	0	3+	2+	2+	×

This Table provides scoring for the different marker antibodies used to diagnose the histopathology of these sarcomas. The markers include S100, cytokeratin (AE1/AE3), smooth muscle actin (SMA), desmin, calponin and p53. All staining was diffuse unless otherwise noted. N/A refers to not applicable. The abbreviations M and F refer to male and female, respectively
NA^* is Not Evaluable and x is Not Done