Fig. 5
From: Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas
Immunohistochemical analyses in human leiomyosarcoma cases and normal vascular smooth muscle and outcomes analysis. a: USP18 staining of normal lung tissue. Blue arrow indicates a USP18 positive macrophage. b: USP18 staining of clinical leiomyosarcoma with adjacent normal smooth muscle tissue. Abundant USP18 expression in vascular smooth muscle cells is highlighted with black arrows. Red arrows indicate leiomyosarcoma. c: Relative levels of USP18 in normal smooth muscle and in a series of leiomyosarcoma. d: Time to development of first metastasis for 89 primary uterine and soft tissue leiomyosarcoma patients