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Table 2 Cox’s proportional hazard regression model for overall survival (OS) and breast cancer specific survival (BCSS)

From: Relationship between body mass index and the expression of hormone receptors or human epidermal growth factor receptor 2 with respect to breast cancer survival

Characteristic Overall survival Breast cancer specific survival
  Alive Death HR (95 % CI) p value Adjust HR (95 % CI) p value Alive Death HR (95 % CI) p value Adjust HR (95 % CI) p value
No. of participants 36553 4468      98197 2824     
Age (years)             
 ≤ 35 3330(9.11) 407(9.11) 1.00     3479(9.11) 258(9.14) 1.00    
 > 35 33223(90.89) 4061(90.89) 1.04(0.94-1.15) 0.4945    34718(90.89) 2566(90.86) 1.03(0.91-1.17) 0.6453   
Tumor size (cm)             
 0 - 2 20608(56.38) 1323(29.61) 1.00   1.00   21185(55.46) 746(26.42) 1.00   1.00  
 > 2 15945(43.62) 3145(70.39) 2.74(2.57-2.92) <0.0001 1.70(1.58-1.82) <0.0001 17012(44.54) 2078(73.58) 3.16(2.91-3.44) <0.0001 1.77(1.61-1.93) <0.0001
Axillary lymph node metastasis             
 Negative 23731(64.92) 1474(32.99) 1.00   1.00   24439(63.98) 766(27.12) 1.00   1.00  
 Positive 12822(35.08) 2994(67.01) 3.43(3.22-3.65) <0.0001 2.95(2.75-3.16) <0.0001 13758(36.02) 2058(72.88) 4.42(4.07-4.80) <0.0001 3.50(3.20-3.84) <0.0001
Operation method             
 Mastectomy 19830(54.25) 3532(79.05) 1.00   1.00   21094(55.22) 2268(80.31) 1.00   1.00  
 Conserving surgery 16723(45.75) 936(20.95) 0.37(0.34-0.39) <0.0001 0.55(0.51-0.59) <0.0001 17103(44.78) 556(19.69) 0.34(0.31-0.37) <0.0001 0.55(0.50-0.61) <0.0001
ER/PR expression             
 ER and/or PR Positive 25647(70.16) 2519(56.38) 1.00   1.00   26629(69.71) 1537(54.43) 1.00   1.00  
 ER and PR Negative 10906(29.84) 1949(43.62) 1.75(1.65-1.86) <0.0001 1.55(1.42-1.70) <0.0001 11568(30.29) 1287(45.57) 1.87(1.73-2.01) <0.0001 1.56(1.40-1.74) <0.0001
HER 2 expression             
 Negative 26098(71.40) 2432(54.43) 1.00   1.00   27018(70.73) 1512(53.54) 1.00   1.00  
 Positive 7040(19.26) 965(21.59) 1.42(1.32-1.53) <0.0001 1.11(1.03-1.20) 0.0061 7402(19.38) 603(21.35) 1.41(1.29-1.55) <0.0001 1.08(0.98-1.19) 0.1128
 Unknown 3415(9.34) 1071(23.97) 2.23(2.07-2.41) <0.0001 1.70(1.58-1.84) <0.0001 3777(9.89) 709(25.10) 2.45(2.23-2.68) <0.0001 1.91(1.74-2.11) <0.0001
BMI calssification             
 Underweight BMI 1229(3.36) 158(3.54) 1.16(0.98-1.36) 0.0784 1.23(1.05-1.44) 0.0118 1284(3.36) 103(3.65) 1.18(0.97-1.44) 0.0974 1.26(1.03-1.54) 0.0219
 Normal BMI 24766(67.75) 2753(61.62) 1.00   1.00   25774(67.48) 1745(61.79) 1.00   1.00  
 Overweight BMI 9164(25.07) 1319(29.52) 1.26(1.18-1.35) <0.0001 1.15(1.07-1.23) <0.0001 9651(25.27) 832(29.46) 1.25(1.15-1.36) <0.0001 1.13(1.04-1.22) 0.0052
 Obese BMI 1394(3.81) 238(5.33) 1.51(1.32-1.72) <0.0001 1.29(1.13-1.48) 0.0002 1488(3.90) 144(5.10) 1.42(1.19-1.68) <0.0001 1.21(1.02-1.43) 0.0321
Histologic grade             
 Low (grade1 - 2) 18316(50.11) 1727(38.65) 1.00   1.00   19002(49.75) 1041(36.86) 1.00   1.00  
 High (Grade 3) 13631(37.29) 2259(50.56) 1.73(1.62-1.84) <0.0001 1.32(1.23-1.41) <0.0001 14401(37.70) 1489(52.73) 1.86(1.72-2.02) <0.0001 1.36(1.25-1.48) <0.0001
 Unknown 4606(12.60) 482(10.79) 1.02(0.92-1.13) 0.6849 1.04(0.94-1.15) 0.494 4794(12.55) 294(10.41) 1.04(0.92-1.19) 0.5269 1.08(0.95-1.23) 0.2561
Adjuvant chemotherapy             
 Yes 25339(69.32) 3473(77.73) 1.00   1.00   26475(69.31) 2337(82.75) 1.00   1.00  
 No 9002(24.63) 680(15.22) 0.58(0.53-0.63) <0.0001 1.41(1.29-1.55) <0.0001 9354(24.49) 328(11.61) 0.42(0.37-0.47) <0.0001 1.12(0.99-1.28) 0.0753
 Unknown 2212(6.05) 315(7.05) 1.02(0.91-1.14) 0.7874 1.09(0.97-1.24) 0.1448 2368(6.20) 159(5.63) 0.75(0.64-0.88) 0.0005 0.79(0.67-0.94) 0.0062
Adjuvant hormonal             
 Yes 23785(65.07) 2480(55.51) 1.00   1.00   24743(64.78) 1522(53.90) 1.00   1.00  
 No 11000(30.09) 1782(39.88) 1.53(1.44-1.63) <0.0001 1.07(0.98-1.17) 0.1399 11604(30.38) 1178(41.71) 1.63(1.51-1.76) <0.0001 1.12(1.01-1.25) 0.0414
 Unknown 1768(4.84) 206(4.61) 1.13(0.98-1.30) 0.0920 1.02(0.88-1.19) 0.7627 1850(4.84) 124(4.39) 1.10(0.92-1.32) 0.3058 1.04(0.86-1.25) 0.6977
  1. Abbreviations: OS overall survival, BCSS breast cancer specific survival, HR hazard ratio
  2. Data presented as n (%) and HR (95 % CI)
  3. HRs are unadjusted or adjusted based on Cox’s proportional-hazard regression models
  4. Patient age; tumor size; histologic grade; lymph node status; operation method; adjuvant treatment; ER/PR status and HER2 expression included in the multivariate analysis model