|
Characteristic
|
Overall survival
|
Breast cancer specific survival
|
|---|
| |
Alive
|
Death
|
HR (95 % CI)
|
p value
|
Adjust HR (95 % CI)
|
p value
|
Alive
|
Death
|
HR (95 % CI)
|
p value
|
Adjust HR (95 % CI)
|
p value
|
|---|
|
No. of participants
|
36553
|
4468
| | | | |
98197
|
2824
| | | | |
|
Age (years)
| | | | | | | | | | | | |
|
≤ 35
|
3330(9.11)
|
407(9.11)
|
1.00
| | | |
3479(9.11)
|
258(9.14)
|
1.00
| | | |
|
> 35
|
33223(90.89)
|
4061(90.89)
|
1.04(0.94-1.15)
|
0.4945
| | |
34718(90.89)
|
2566(90.86)
|
1.03(0.91-1.17)
|
0.6453
| | |
|
Tumor size (cm)
| | | | | | | | | | | | |
|
0 - 2
|
20608(56.38)
|
1323(29.61)
|
1.00
| |
1.00
| |
21185(55.46)
|
746(26.42)
|
1.00
| |
1.00
| |
|
> 2
|
15945(43.62)
|
3145(70.39)
|
2.74(2.57-2.92)
|
<0.0001
|
1.70(1.58-1.82)
|
<0.0001
|
17012(44.54)
|
2078(73.58)
|
3.16(2.91-3.44)
|
<0.0001
|
1.77(1.61-1.93)
|
<0.0001
|
|
Axillary lymph node metastasis
| | | | | | | | | | | | |
|
Negative
|
23731(64.92)
|
1474(32.99)
|
1.00
| |
1.00
| |
24439(63.98)
|
766(27.12)
|
1.00
| |
1.00
| |
|
Positive
|
12822(35.08)
|
2994(67.01)
|
3.43(3.22-3.65)
|
<0.0001
|
2.95(2.75-3.16)
|
<0.0001
|
13758(36.02)
|
2058(72.88)
|
4.42(4.07-4.80)
|
<0.0001
|
3.50(3.20-3.84)
|
<0.0001
|
|
Operation method
| | | | | | | | | | | | |
|
Mastectomy
|
19830(54.25)
|
3532(79.05)
|
1.00
| |
1.00
| |
21094(55.22)
|
2268(80.31)
|
1.00
| |
1.00
| |
|
Conserving surgery
|
16723(45.75)
|
936(20.95)
|
0.37(0.34-0.39)
|
<0.0001
|
0.55(0.51-0.59)
|
<0.0001
|
17103(44.78)
|
556(19.69)
|
0.34(0.31-0.37)
|
<0.0001
|
0.55(0.50-0.61)
|
<0.0001
|
|
ER/PR expression
| | | | | | | | | | | | |
|
ER and/or PR Positive
|
25647(70.16)
|
2519(56.38)
|
1.00
| |
1.00
| |
26629(69.71)
|
1537(54.43)
|
1.00
| |
1.00
| |
|
ER and PR Negative
|
10906(29.84)
|
1949(43.62)
|
1.75(1.65-1.86)
|
<0.0001
|
1.55(1.42-1.70)
|
<0.0001
|
11568(30.29)
|
1287(45.57)
|
1.87(1.73-2.01)
|
<0.0001
|
1.56(1.40-1.74)
|
<0.0001
|
|
HER 2 expression
| | | | | | | | | | | | |
|
Negative
|
26098(71.40)
|
2432(54.43)
|
1.00
| |
1.00
| |
27018(70.73)
|
1512(53.54)
|
1.00
| |
1.00
| |
|
Positive
|
7040(19.26)
|
965(21.59)
|
1.42(1.32-1.53)
|
<0.0001
|
1.11(1.03-1.20)
|
0.0061
|
7402(19.38)
|
603(21.35)
|
1.41(1.29-1.55)
|
<0.0001
|
1.08(0.98-1.19)
|
0.1128
|
|
Unknown
|
3415(9.34)
|
1071(23.97)
|
2.23(2.07-2.41)
|
<0.0001
|
1.70(1.58-1.84)
|
<0.0001
|
3777(9.89)
|
709(25.10)
|
2.45(2.23-2.68)
|
<0.0001
|
1.91(1.74-2.11)
|
<0.0001
|
|
BMI calssification
| | | | | | | | | | | | |
|
Underweight BMI
|
1229(3.36)
|
158(3.54)
|
1.16(0.98-1.36)
|
0.0784
|
1.23(1.05-1.44)
|
0.0118
|
1284(3.36)
|
103(3.65)
|
1.18(0.97-1.44)
|
0.0974
|
1.26(1.03-1.54)
|
0.0219
|
|
Normal BMI
|
24766(67.75)
|
2753(61.62)
|
1.00
| |
1.00
| |
25774(67.48)
|
1745(61.79)
|
1.00
| |
1.00
| |
|
Overweight BMI
|
9164(25.07)
|
1319(29.52)
|
1.26(1.18-1.35)
|
<0.0001
|
1.15(1.07-1.23)
|
<0.0001
|
9651(25.27)
|
832(29.46)
|
1.25(1.15-1.36)
|
<0.0001
|
1.13(1.04-1.22)
|
0.0052
|
|
Obese BMI
|
1394(3.81)
|
238(5.33)
|
1.51(1.32-1.72)
|
<0.0001
|
1.29(1.13-1.48)
|
0.0002
|
1488(3.90)
|
144(5.10)
|
1.42(1.19-1.68)
|
<0.0001
|
1.21(1.02-1.43)
|
0.0321
|
|
Histologic grade
| | | | | | | | | | | | |
|
Low (grade1 - 2)
|
18316(50.11)
|
1727(38.65)
|
1.00
| |
1.00
| |
19002(49.75)
|
1041(36.86)
|
1.00
| |
1.00
| |
|
High (Grade 3)
|
13631(37.29)
|
2259(50.56)
|
1.73(1.62-1.84)
|
<0.0001
|
1.32(1.23-1.41)
|
<0.0001
|
14401(37.70)
|
1489(52.73)
|
1.86(1.72-2.02)
|
<0.0001
|
1.36(1.25-1.48)
|
<0.0001
|
|
Unknown
|
4606(12.60)
|
482(10.79)
|
1.02(0.92-1.13)
|
0.6849
|
1.04(0.94-1.15)
|
0.494
|
4794(12.55)
|
294(10.41)
|
1.04(0.92-1.19)
|
0.5269
|
1.08(0.95-1.23)
|
0.2561
|
|
Adjuvant chemotherapy
| | | | | | | | | | | | |
|
Yes
|
25339(69.32)
|
3473(77.73)
|
1.00
| |
1.00
| |
26475(69.31)
|
2337(82.75)
|
1.00
| |
1.00
| |
|
No
|
9002(24.63)
|
680(15.22)
|
0.58(0.53-0.63)
|
<0.0001
|
1.41(1.29-1.55)
|
<0.0001
|
9354(24.49)
|
328(11.61)
|
0.42(0.37-0.47)
|
<0.0001
|
1.12(0.99-1.28)
|
0.0753
|
|
Unknown
|
2212(6.05)
|
315(7.05)
|
1.02(0.91-1.14)
|
0.7874
|
1.09(0.97-1.24)
|
0.1448
|
2368(6.20)
|
159(5.63)
|
0.75(0.64-0.88)
|
0.0005
|
0.79(0.67-0.94)
|
0.0062
|
|
Adjuvant hormonal
| | | | | | | | | | | | |
|
Yes
|
23785(65.07)
|
2480(55.51)
|
1.00
| |
1.00
| |
24743(64.78)
|
1522(53.90)
|
1.00
| |
1.00
| |
|
No
|
11000(30.09)
|
1782(39.88)
|
1.53(1.44-1.63)
|
<0.0001
|
1.07(0.98-1.17)
|
0.1399
|
11604(30.38)
|
1178(41.71)
|
1.63(1.51-1.76)
|
<0.0001
|
1.12(1.01-1.25)
|
0.0414
|
|
Unknown
|
1768(4.84)
|
206(4.61)
|
1.13(0.98-1.30)
|
0.0920
|
1.02(0.88-1.19)
|
0.7627
|
1850(4.84)
|
124(4.39)
|
1.10(0.92-1.32)
|
0.3058
|
1.04(0.86-1.25)
|
0.6977
|
- Abbreviations: OS overall survival, BCSS breast cancer specific survival, HR hazard ratio
- Data presented as n (%) and HR (95 % CI)
- HRs are unadjusted or adjusted based on Cox’s proportional-hazard regression models
- Patient age; tumor size; histologic grade; lymph node status; operation method; adjuvant treatment; ER/PR status and HER2 expression included in the multivariate analysis model
