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Table 1 General characteristics of KBCS breast cancer subjects, overall and by BMI categories

From: Relationship between body mass index and the expression of hormone receptors or human epidermal growth factor receptor 2 with respect to breast cancer survival

Characteristic

Overall

Underweight BMI

Normal BMI

Overweight BMI

Obese BMI

p value

<18.5 kg/m2

18.5-24.9 kg/m2

25-29.9 kg/m2

≥30 kg/m2

No. of subjects

41021

1387

27519

10483

1632

 

Age (years)

      

 mean(SD)

48(10)

42(10)

47(10)

52(10)

53(11)

<0.0001

 Median(Range)

47(18-93)

41(19-87)

46(18-93)

51(19-90)

53(22-87)

 

 ≤ 35

3737(9.11)

390(28.12)

2793(10.15)

483(4.61)

71(4.35)

<0.0001

 > 35

37284(90.89)

997(71.88)

24726(89.85)

10000(95.39)

1561(95.65)

 

Tumor size (cm)

      

 0 - 2

21931(53.46)

827(59.63)

15331(55.71)

5083(48.49)

690(42.28)

<0.0001

 > 2

19090(46.54)

560(40.37)

12188(44.29)

5400(51.51)

942(57.72)

 

Axillary lymph node metastasis

      

 Negative

25205(61.44)

916(66.04)

17205(62.52)

6153(58.70)

931(57.05)

<0.0001

 Positive

15816(38.56)

471(33.96)

10314(37.48)

4330(41.30)

701(42.95)

 

Operation method

      

 Mastectomy

23362(56.95)

759(54.72)

15361(55.82)

6254(59.66)

988(60.54)

<0.0001

 Conserving surgery

17659(43.05)

628(45.28)

12158(44.18)

4229(40.34)

644(39.46)

 

ER/PR expression

      

 ER and/or PR Positive

28166(68.66)

970(69.94)

19065(69.28)

7040(67.16)

1091(66.85)

0.0002

 ER and PR Negative

12855(31.34)

417(30.06)

8454(30.72)

3443(32.84)

541(33.15)

 

HER 2 expression

      

 Negative

28530(69.55)

955(68.85)

18995(69.03)

7401(70.60)

1179(72.24)

0.0004

 Positive

8005(19.51)

265(19.11)

5541(20.14)

1917(18.29)

282(17.28)

 

 Unknown

4486(10.94)

167(12.04)

2983(10.84)

1165(11.11)

171(10.48)

 

Subtype

      

 ER and/or PR + and HER 2 -

21094(51.42)

706(50.90)

14179(51.52)

5363(51.16)

846(51.84)

<0.0001

 ER and/or PR + and HER 2 +

4118(10.04)

144(10.38)

2909(10.57)

929(8.86)

136(8.33)

 

 ER and PR - and HER 2 +

3887(9.48)

121(8.72)

2632(9.56)

988(9.42)

146(8.95)

 

 ER and PR - and HER 2 - -

7436(18.13)

249(17.95)

4816(17.50)

2038(19.44)

333(20.40)

 

 Unknown

4486(10.94)

167(12.04)

2983(10.84)

1165(11.11)

171(10.48)

 

Histologic grade

      

 Low (grade1 - 2)

20043(48.86)

690(49.75)

13495(49.04)

5050(48.17)

808(49.51)

0.0032

 High (Grade 3)

15890(38.74)

498(35.90)

10560(38.37)

4186(39.93)

646(39.58)

 

 Unknown

5088(12.4)

199(14.35)

3464(12.59)

1247(11.90)

178(10.91)

 

Adjuvant chemotherapy

      

 Yes

28812(70.24)

891(64.24)

19289(70.09)

7477(71.33)

1155(70.77)

<0.0001

 No

9682(23.6)

409(29.49)

6578(23.90)

2320(22.13)

375(22.98)

 

 Unknown

2527(6.16)

87(6.27)

1652(6.00)

686(6.54)

102(6.25)

 

Adjuvant hormonal

      

 Yes

26265(64.03)

856(61.72)

17723(64.40)

6651(63.45)

1035(63.42)

0.2424

 No

12782(31.16)

463(33.38)

8501(30.89)

3300(31.48)

518(31.74)

 

 Unknown

1974(4.81)

68(4.90)

1295(4.71)

532(5.07)

79(4.84)

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