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Table 1 General characteristics of KBCS breast cancer subjects, overall and by BMI categories

From: Relationship between body mass index and the expression of hormone receptors or human epidermal growth factor receptor 2 with respect to breast cancer survival

Characteristic Overall Underweight BMI Normal BMI Overweight BMI Obese BMI p value
<18.5 kg/m2 18.5-24.9 kg/m2 25-29.9 kg/m2 ≥30 kg/m2
No. of subjects 41021 1387 27519 10483 1632  
Age (years)       
 mean(SD) 48(10) 42(10) 47(10) 52(10) 53(11) <0.0001
 Median(Range) 47(18-93) 41(19-87) 46(18-93) 51(19-90) 53(22-87)  
 ≤ 35 3737(9.11) 390(28.12) 2793(10.15) 483(4.61) 71(4.35) <0.0001
 > 35 37284(90.89) 997(71.88) 24726(89.85) 10000(95.39) 1561(95.65)  
Tumor size (cm)       
 0 - 2 21931(53.46) 827(59.63) 15331(55.71) 5083(48.49) 690(42.28) <0.0001
 > 2 19090(46.54) 560(40.37) 12188(44.29) 5400(51.51) 942(57.72)  
Axillary lymph node metastasis       
 Negative 25205(61.44) 916(66.04) 17205(62.52) 6153(58.70) 931(57.05) <0.0001
 Positive 15816(38.56) 471(33.96) 10314(37.48) 4330(41.30) 701(42.95)  
Operation method       
 Mastectomy 23362(56.95) 759(54.72) 15361(55.82) 6254(59.66) 988(60.54) <0.0001
 Conserving surgery 17659(43.05) 628(45.28) 12158(44.18) 4229(40.34) 644(39.46)  
ER/PR expression       
 ER and/or PR Positive 28166(68.66) 970(69.94) 19065(69.28) 7040(67.16) 1091(66.85) 0.0002
 ER and PR Negative 12855(31.34) 417(30.06) 8454(30.72) 3443(32.84) 541(33.15)  
HER 2 expression       
 Negative 28530(69.55) 955(68.85) 18995(69.03) 7401(70.60) 1179(72.24) 0.0004
 Positive 8005(19.51) 265(19.11) 5541(20.14) 1917(18.29) 282(17.28)  
 Unknown 4486(10.94) 167(12.04) 2983(10.84) 1165(11.11) 171(10.48)  
Subtype       
 ER and/or PR + and HER 2 - 21094(51.42) 706(50.90) 14179(51.52) 5363(51.16) 846(51.84) <0.0001
 ER and/or PR + and HER 2 + 4118(10.04) 144(10.38) 2909(10.57) 929(8.86) 136(8.33)  
 ER and PR - and HER 2 + 3887(9.48) 121(8.72) 2632(9.56) 988(9.42) 146(8.95)  
 ER and PR - and HER 2 - - 7436(18.13) 249(17.95) 4816(17.50) 2038(19.44) 333(20.40)  
 Unknown 4486(10.94) 167(12.04) 2983(10.84) 1165(11.11) 171(10.48)  
Histologic grade       
 Low (grade1 - 2) 20043(48.86) 690(49.75) 13495(49.04) 5050(48.17) 808(49.51) 0.0032
 High (Grade 3) 15890(38.74) 498(35.90) 10560(38.37) 4186(39.93) 646(39.58)  
 Unknown 5088(12.4) 199(14.35) 3464(12.59) 1247(11.90) 178(10.91)  
Adjuvant chemotherapy       
 Yes 28812(70.24) 891(64.24) 19289(70.09) 7477(71.33) 1155(70.77) <0.0001
 No 9682(23.6) 409(29.49) 6578(23.90) 2320(22.13) 375(22.98)  
 Unknown 2527(6.16) 87(6.27) 1652(6.00) 686(6.54) 102(6.25)  
Adjuvant hormonal       
 Yes 26265(64.03) 856(61.72) 17723(64.40) 6651(63.45) 1035(63.42) 0.2424
 No 12782(31.16) 463(33.38) 8501(30.89) 3300(31.48) 518(31.74)  
 Unknown 1974(4.81) 68(4.90) 1295(4.71) 532(5.07) 79(4.84)