Fig. 2

Effects of SOX4 knockdown (SOX4-KO) on cell invasion and migration in head and neck squamous cell carcinoma cells. a In the cell invasion assay, significantly fewer SOX4-KO PCI50 and SNU1041 cells invaded than did negative control cells. Stained invading cells were counted (bar graph; mean ± SE, experiments were run in triplicate; ^*P < 0.05). b Cell migration was significantly less in SOX4-KO PCI50 and SNU1041 cells than in negative control cells (displayed as relative healing distances measured in three random sites). Values indicate mean ± SE for three independent experiments (^*P < 0.05). C: negative control siRNA transfected cells; S: SOX4-specific siRNA transfected cells (SOX4-KO)