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Fig. 1 | BMC Cancer

Fig. 1

From: SOX4 expression is associated with treatment failure and chemoradioresistance in oral squamous cell carcinoma

Fig. 1

Effect of SOX4 knockdown on cell proliferation and apoptosis in head and neck squamous cell carcinoma (HNSCC) cells. a SOX4 protein and mRNA were well-expressed in HNSCC cells, PCI50 and SNU1041 cells, but not in normal keratinocyte, HaCaT cells. b SOX4 protein and mRNA expressions were reduced by SOX4 siRNA (SOX4-KO) in PCI50 and SNU 1041 cells compared with negative control siRNA. c Absorbance indicates that proliferation was decreased in SOX4-KO PCI50 and SNU1041 cells compared with negative control cells (mean ± SE, *P < 0.05; experiments were run in triplicate). d SOX4-KO PCI50 and SNU1041 cells displayed more apoptosis than in control cells. e Levels of cleaved caspases-3 and −7, and cleaved poly-ADP ribose polymerase (PARP) were greater, and X-linked inhibitor of apoptosis protein (XIAP) was less, in SOX4-KO PCI50 and SNU1041 cells than in control cells. C: negative control siRNA transfected cells; S: SOX4-specific siRNA transfected cells (SOX4-KO)

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