Fig. 1From: SOX4 expression is associated with treatment failure and chemoradioresistance in oral squamous cell carcinomaEffect of SOX4 knockdown on cell proliferation and apoptosis in head and neck squamous cell carcinoma (HNSCC) cells. a SOX4 protein and mRNA were well-expressed in HNSCC cells, PCI50 and SNU1041 cells, but not in normal keratinocyte, HaCaT cells. b SOX4 protein and mRNA expressions were reduced by SOX4 siRNA (SOX4-KO) in PCI50 and SNU 1041 cells compared with negative control siRNA. c Absorbance indicates that proliferation was decreased in SOX4-KO PCI50 and SNU1041 cells compared with negative control cells (mean ± SE, *P < 0.05; experiments were run in triplicate). d SOX4-KO PCI50 and SNU1041 cells displayed more apoptosis than in control cells. e Levels of cleaved caspases-3 and −7, and cleaved poly-ADP ribose polymerase (PARP) were greater, and X-linked inhibitor of apoptosis protein (XIAP) was less, in SOX4-KO PCI50 and SNU1041 cells than in control cells. C: negative control siRNA transfected cells; S: SOX4-specific siRNA transfected cells (SOX4-KO)Back to article page