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Table 2 PSA response and outcome after ADT with or without selective estrogen receptor modulators (n = 15)

From: Toremifene, a selective estrogen receptor modulator, significantly improved biochemical recurrence in bone metastatic prostate cancer: a randomized controlled phase II a trial

 

ADT (n = 5)

TOPADT (n = 5)

RAPADT (n = 5)

Follow-up period (median, range)

1169 (431―1631)

1653 (730―1983)

1570 (750―1883)

PSA nadir (ng/mL)

≥1

1

0

1

0.01–1.0

2

3

3

≤0.01

2

2

1

Biochemical recurrence

No

2

5

3

Yes

3

0

2

Outcome

Alive with disease

4

4

5

Died of PC

1

0

0

Died of other disease

0

1: Died of gastric cancer

0

Adverse event

 

Hot flush: 2

Hot flush: 3, Headache: 1

Hot flush: 3

  1. ADT androgen deprivation therapy including surgical or medical castration plus bicalutamide, TOPADT toremifene plus ADT, RAPADT raloxifene plus ADT, PC prostate cancer