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Fig. 7 | BMC Cancer

Fig. 7

From: A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties

Fig. 7

The fumarate moiety of GTCpFE is required for the NFκB inhibition in breast cancer cells. a Structural analogs of GTCpFE are indicated. b NFκB-RE activity was measured in MCF-7 cells following treatment with TNFα and the analogs shown in (A) 20 μM each. c RT-QPCR for ICAM1 gene expression was measured in MCF-7 cells treated as in (B). d MS formation of MCF-7 cells treated with 20 μM GTCpFE, ASA, BzFE, and GTCpSE demonstrate attenuated MS growth. Quantitation of MS growth (left panel) and representative pictures (20×) of MS (right panel) are shown. The different letters above bars (a, b, c) indicate significant difference between treatments, P < 0.05

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