Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling

Fig. 4

Downregulation of TLR4 inhibits the growth of HepG2.2.15-derived xenografts in athymic nude mice. HepG2.2.15 transfectants expressing replication-defective recombinant lentiviral carrying the TLR4-shRNA(Le-TLR4) or replication-defective recombinant lentiviral carrying the negative control shRNA(Le-NC) were inoculated s.c. into immunodeficient mice. a Macrographic images of the HepG2.2.15 subcutaneous tumor xenografts in each mouse; b The size of subcutaneous tumor xenografts from each mouse; (n = 5 per group). c Growth curves of the tumor xenografts, volume of denuded tumor xenografts, volume of Le-TLR4 group reduced significantly compared to control shRNA (Le-NC) group and normal saline group. d Weight of denuded tumor xenografts, weight of Le-TLR4 group reduced significantly compared to control shRNA (Le-NC) group and normal saline group. e and f Volume and weight of tumor xenografts was not changed in nude mice received HepG2 cells **P < 0.01, compared with Le-NC group

Back to article page