Table 1 Clinicopathological charasteristics of 135 CRLM patients
Variable | All cases | Peritumoral MCs | p value | |
|---|---|---|---|---|
Low | High | |||
Number of patients | 135 | 62 | 73 | Â |
Age, years | 63.4 ± 10.0 | 63.4 ± 10.1 | 63.5 ± 10.0 | 0.99 |
Sex [n (%)] | Â | Â | Â | 0.60 |
 Male | 84 (62.2) | 37 (59.7) | 47 (64.4) |  |
 Female | 51 (37.8) | 25 (40.3) | 26 (35.6) |  |
Location of primary tumor [n (%)] | Â | Â | Â | 0.90 |
 Colon | 89 (65.9) | 41 (66.1) | 48 (65.8) |  |
 Rectum | 46 (34.1) | 21 (33.9) | 25 (34.2) |  |
Primary lymph node metastases [n (%)] | Â | Â | Â | 0.58 |
 Negative | 44 (32.6) | 22 (35.5) | 22 (30.1) |  |
 Positive | 91 (67.4) | 40 (64.5) | 51 (69.9) |  |
Timing [n (%)] | Â | Â | Â | 0.06 |
 Synchronous | 78 (57.8) | 30 (48.4) | 48 (65.8) |  |
 Metachronous | 57 (42.2) | 32 (51.6) | 25 (34.2) |  |
Distribution [n (%)] | Â | Â | Â | 0.16 |
 Uniloblar | 56 (41.5) | 30 (48.4) | 26 (35.6) |  |
 Biloblar | 79 (58.5) | 32 (51.6) | 47 (64.4) |  |
Tumor number | 5.7 ± 6.1 | 4.8 ± 5.6 | 6.4 ± 6.4 | 0.13 |
Maximum tumor size, mm | 39.2 ± 24.6 | 38.3 ± 23.2 | 39.9 ± 25.8 | 0.70 |
Extrahepatic metastases [n (%)] | Â | Â | Â | 0.11 |
 Present | 33 (24.4) | 11 (17.7) | 22 (30.1) |  |
 Absent | 102 (75.6) | 51 (82.3) | 51 (69.9) |  |
Preoperative chemotherapy [n (%)] | Â | Â | Â | 0.30 |
 Yes | 70 (51.9) | 29 (47.5) | 41 (56.9) |  |
 No | 65 (48.1) | 32 (52.5) | 31 (43.1) |  |
Prehepatectomy CRP, mg/L | 0.6 ± 1.3 | 0.7 ± 1.5 | 0.6 ± 1.2 | 0.62 |
Prehepatectomy Alb, g/dL | 4.0 ± 0.4 | 4.0 ± 0.4 | 4.0 ± 0.5 | 0.53 |
Prehepatectomy CEA, ng/mL | 201.1 ± 607.1 | 111.2 ± 341 | 277 ± 758.0 | 0.10 |
Peritumoral MCs | 42.2 ± 36.8 | 11.2 ± 5.2 | 68.4 ± 31.1 | <0.01 |
Normal liver areal MCs | 13.6 ± 9.9 | 11.4 ± 8.6 | 15.5 ± 10.6 | 0.02 |
Peritumoral Mφs | 113.2 ± 105.1 | 93.4 ± 99.1 | 130.0 ± 107.7 | 0.04 |
Peritumoral mature DCs | 7.6 ± 8.7 | 8.2 ± 6.9 | 7.1 ± 10.0 | 0.43 |
Micro vessel density | 39.6 ± 24.9 | 32.0 ± 16.6 | 46.0 ± 28.9 | <0.01 |