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Table 4 Age- and BMI-adjusted means of mammographic density (MD) in the breast contralateral to the primary pathologic diagnosis in relation to relative LTL

From: Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

   All women (N = 195) Proliferative diagnosis1 (N = 141) Non-proliferative diagnosis2 (N = 54)
Measure of MD Binary LTL Mean MD§ (95 % CI)§ Mean MD§ (95 % CI)§ Mean MD§ (95 % CI)§
% density (volume) <1.20 37.81 (34.43, 41.34) 38.70 (34.47, 43.18) 36.48 (30.84, 42.59)
  ≥1.20 39.22 (36.58, 41.94) 39.07 (36.15, 42.12) 39.57 (33.69, 45.93)
  P-trend 0.529 0.89 0.475
Dense volume (cm3) <1.20 182.28 (164.16, 201.35) 185.62 (162.26, 210.55) 175.14 (146.99, 205.75)
  ≥1.20 185.24 (171.22, 199.81) 184.83 (168.77, 201.63) 188.37 (159.13, 220.08)
  P-trend 0.805 0.958 0.540
Total breast volume (cm3) <1.20 538.44 (487.35, 592.08) 538.35 (472.00, 609.05) 531.91 (452.82, 617.38)
  ≥1.20 549.25 (509.65, 590.33) 548.35 (502.20, 596.52) 559.27 (478.09, 646.82)
  P-trend 0.749 0.814 0.649
% density (area) <1.20 26.98 (23.15, 31.11) 25.99 (21.21, 31.26) 28.84 (22.38, 36.12)
  ≥1.20 26.25 (23.34, 29.33) 25.92 (22.61, 29.46) 27.27 (20.99, 34.36)
  P-trend 0.774 0.983 0.748
Dense area (cm2) <1.20 32.96 (27.71, 38.65) 32.22 (25.83, 39.31) 34.20 (24.87, 44.00)
  ≥1.20 30.97 (27.06, 35.15) 30.79 (26.46, 35.45) 31.62 (22.68, 42.04)
  P-trend 0.566 0.729 0.718
Total breast area (cm2) <1.20 132.35 (122.72, 142.36) 135.33 (122.76, 148.52) 126.28 (111.12, 142.40)
  ≥1.20 133.99 (126.56, 141.64) 135.66 (127.01, 144.60) 129.33 (113.98, 145.64)
  P-trend 0.796 0.967 0.788
  1. 1Diagnosis of hyperplasia, in-situ cancer or invasive cancer
  2. 2Diagnosis of benign or other discrete non-proliferative diagnosis
  3. §Based on a linear regression using square root of the density measure as outcome. Results are back-transformed. Adjusted for age (continuous) and BMI (continuous)
  4. Telomere length was divided at the median levels in subjects with non