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Table 4 Age- and BMI-adjusted means of mammographic density (MD) in the breast contralateral to the primary pathologic diagnosis in relation to relative LTL

From: Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

  

All women

(N = 195)

Proliferative diagnosis1

(N = 141)

Non-proliferative diagnosis2 (N = 54)

Measure of MD

Binary LTL

Mean MD§

(95 % CI)§

Mean MD§

(95 % CI)§

Mean MD§

(95 % CI)§

% density (volume)

<1.20

37.81

(34.43, 41.34)

38.70

(34.47, 43.18)

36.48

(30.84, 42.59)

 

≥1.20

39.22

(36.58, 41.94)

39.07

(36.15, 42.12)

39.57

(33.69, 45.93)

 

P-trend

0.529

0.89

0.475

Dense volume (cm3)

<1.20

182.28

(164.16, 201.35)

185.62

(162.26, 210.55)

175.14

(146.99, 205.75)

 

≥1.20

185.24

(171.22, 199.81)

184.83

(168.77, 201.63)

188.37

(159.13, 220.08)

 

P-trend

0.805

0.958

0.540

Total breast volume (cm3)

<1.20

538.44

(487.35, 592.08)

538.35

(472.00, 609.05)

531.91

(452.82, 617.38)

 

≥1.20

549.25

(509.65, 590.33)

548.35

(502.20, 596.52)

559.27

(478.09, 646.82)

 

P-trend

0.749

0.814

0.649

% density (area)

<1.20

26.98

(23.15, 31.11)

25.99

(21.21, 31.26)

28.84

(22.38, 36.12)

 

≥1.20

26.25

(23.34, 29.33)

25.92

(22.61, 29.46)

27.27

(20.99, 34.36)

 

P-trend

0.774

0.983

0.748

Dense area (cm2)

<1.20

32.96

(27.71, 38.65)

32.22

(25.83, 39.31)

34.20

(24.87, 44.00)

 

≥1.20

30.97

(27.06, 35.15)

30.79

(26.46, 35.45)

31.62

(22.68, 42.04)

 

P-trend

0.566

0.729

0.718

Total breast area (cm2)

<1.20

132.35

(122.72, 142.36)

135.33

(122.76, 148.52)

126.28

(111.12, 142.40)

 

≥1.20

133.99

(126.56, 141.64)

135.66

(127.01, 144.60)

129.33

(113.98, 145.64)

 

P-trend

0.796

0.967

0.788

  1. 1Diagnosis of hyperplasia, in-situ cancer or invasive cancer
  2. 2Diagnosis of benign or other discrete non-proliferative diagnosis
  3. §Based on a linear regression using square root of the density measure as outcome. Results are back-transformed. Adjusted for age (continuous) and BMI (continuous)
  4. Telomere length was divided at the median levels in subjects with non