TY - JOUR AU - Acar, Ömer AU - Özkurt, Ezgi AU - Demir, Gulfem AU - Saraç, Hilal AU - Alkan, Can AU - Esen, Tarık AU - Somel, Mehmet AU - Lack, Nathan A. PY - 2015 DA - 2015/11/09 TI - Determining the origin of synchronous multifocal bladder cancer by exome sequencing JO - BMC Cancer SP - 871 VL - 15 IS - 1 AB - Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is unclear which model is correct, with several studies supporting both hypotheses. A potential cause of this uncertainty may be the small number of genetic mutations previously used to quantify the relationship between these tumours. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-015-1859-8 DO - 10.1186/s12885-015-1859-8 ID - Acar2015 ER -