From: Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer
Differentially expressed proteins not previously reported in GBC | ||||||
Gene symbol | Protein name | Function | Fold change | |||
OCUG-1/ TGBC 24TKB | NOZ/ TGBC 24TKB | GB-d1/ TGBC 24TKB | ||||
MIF | Macrophage migration inhibitory factor | Pro-inflammatory cytokine | 3.9 | 4.9 | 1.4 | |
CALD1 | Caldesmon | Calmodulin-binding protein | 3.6 | 1.9 | 4.2 | |
DSC2 | Desmocollin-2 | Calcium-dependent glycoprotein required for cell adhesion and desmosome formation | 0.2 | 0.2 | 0.3 | |
PKP2 | Plakophilin-2 | Cell adhesion molecule involved in linking cadherins to intermediate filaments in the cytoskeleton | 0.4 | 0.5 | 0.4 | |
Differentially expressed proteins previously reported in GBC | ||||||
Gene symbol | Protein name | Function | Fold change | Citation | ||
OCUG-1/ TGBC 24TKB | NOZ/ TGBC 24TKB | GB-d1/ TGBC 24TKB | ||||
CD44 | CD44 antigen | Cell-cell interactions, cell adhesion and migration; cancer stem cell marker | 2.2 | 3.0 | 2.2 | Ylagan et. al., 2000 [34] |
MMP1 | Matrix metallo peptidase 1 | Breakdown of extracellular matrix | 2.7 | 2.1 | 2.5 | Du et. al.,2011 [35] |
CDH1 | Cadherin-1 | Cell adhesion, epithelial cell marker | 0.2 | 0.3 | 0.5 | Hirata et. al., 2006 [36] |