Fig. 6
From: Targeting glycolysis by 3-bromopyruvate improves tamoxifen cytotoxicity of breast cancer cell lines
Effect of TAM, 3-BP and their combination on the level HIF-1α. The expression level of HIF-1α in MCF-7 and T47D cells (a, b). The effect of different treatments on the protein level (c, d). Results are expressed as means ± SD of 2 independent experiments performed in duplicates for qPCR experiment. The results for western blot are expressed as means ± SD of 3 independent experiments. Significance was done by one way ANOVA using Tukey’s multiple comparison test. “a” Significantly different from control, “b” from 3-BP and “c” from TAM at P ≤ 0.05. ♦ means synergistic and * potentiation interaction when TAM and 3-BP where combined using factorial design