Table 6 Risk of fracture associated with different types of ADT
Adjusted OR (95 % CI) any fracturea | Adjusted OR (95 % CI) accidental fracturea | Adjusted OR (95 % CI) hip fracturea | |
|---|---|---|---|
No ADT | 1.0 (Reference) | 1.0 (Reference) | 1.0 (Reference) |
GnRH agonists + anti-androgens | 3.48 (3.07–3.96) | 1.60 (1.36–1.88) | 1.82 (1.39–2.38) |
GnRH agonist only | 1.33 (1.09–1.63) | 1.17 (0.93–1.47) | 1.70 (1.19–2.42) |
Anti-androgen only | 2.11 (1.72–2.59) | 1.37 (1.07–1.77) | 1.81 (1.24–2.63) |
Orchiectomy alone | 2.54 (1.76–3.66) | 2.18 (1.43–3.33) | 1.88 (0.96–3.67) |
Orchiectomy + pharmacologic ADT | 4.32 (3.34–5.58) | 1.39 (0.93–2.07) | 1.59 (0.86–2.93) |