Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

Table 3 Correlation between tumor expression of IAPs and caspases and clinicopahological features

	cIAP1/2		cIAP2		NAIP		Survivin		XIAP
	r	p	r	p	r	p	r	p	r	p
Preoperative serum PSA	−0.066	0.549	−0.017	0.877	0.069	0.531	0.185	0.091	−0.025	0.228
Pathological T stage	0.219	0.045*	0.019	0.866	0.037	0.735	0.101	0.362	−0.136	0.218
Clinical T stage	0.103	0.349	0.034	0.759	0.118	0.287	0.090	0.414	0.089	0.419
Gleason score	0.153	0.165	−0.124	0.262	0.052	0.641	−0.172	0.118	0.084	0.446
Perineural invasion	0.110	0.320	0.066	0.551	0.079	0.476	0.229	0.036*	−0.088	0.426
Node involvement	0.122	0.267	0.000	1.000	0.047	0.672	−0.025	0.824	0.030	0.455
Positive surgical margins	0.066	0.549	0.222	0.042*	0.127	0.251	0.055	0.619	−0.179	0.109
Biochemical progresion	−0.002	0.983	0.086	0.438	−0.041	0.711	0.188	0.086	−0.210	0.056
Survival	−0.090	0.414	−0.077	0.489	0.119	0.281	0.239	0.019*	−0.331	0.002*

Correlations between immunohistochemical variables (according to the stratification shown in Table 2) and preoperative serum PSA, pathological T stage, clinical T stage and Gleason score were evaluated by Spearman’s test (r, correlation coefficient). *p < 0.05. (Note: significant correlations after Bonferroni correction should be those with a p < 0.005)

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