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Table 2 Dose modification scheme adapted to severity of adverse events

From: CoCStom trial: study protocol for a randomised trial comparing completeness of adjuvant chemotherapy after early versus late diverting stoma closure in low anterior resection for rectal cancer

 

Grade 2

Grade 3

Grade 4

1. occurrence

Withold therapy until AE has resolved to grade 0–1.

Withold therapy until AE has resolved to grade 0–1.

Withold therapy until AE has resolved to grade 0–1.

Continue with 100 % of the starting dose.

Continue with 75 % of the starting dose

Continue with 50 % of the starting dose

2. occurrence

Withold therapy until AE has resolved to grade 0–1.

Withold therapy until AE has resolved to grade 0–1.

Stop treatment.

Continue with 75 % of the starting dose.

Continue with 50 % of the starting dose.

3. occurrence

Stop treatment

Stop treatment

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