| Grade 2 | Grade 3 | Grade 4 |
---|---|---|---|
1. occurrence | Withold therapy until AE has resolved to grade 0–1. | Withold therapy until AE has resolved to grade 0–1. | Withold therapy until AE has resolved to grade 0–1. |
Continue with 100Â % of the starting dose. | Continue with 75Â % of the starting dose | Continue with 50Â % of the starting dose | |
2. occurrence | Withold therapy until AE has resolved to grade 0–1. | Withold therapy until AE has resolved to grade 0–1. | Stop treatment. |
Continue with 75Â % of the starting dose. | Continue with 50Â % of the starting dose. | ||
3. occurrence | Stop treatment | Stop treatment | Â |