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Fig. 1 | BMC Cancer

Fig. 1

From: CoCStom trial: study protocol for a randomised trial comparing completeness of adjuvant chemotherapy after early versus late diverting stoma closure in low anterior resection for rectal cancer

Fig. 1

Expected patient flow from screening to final analysis. Early closure group: stoma closure and first chemotherapy (CTx) will be done around 2 days and within 4 (earliest) to 12 (latest) weeks respectively after randomisation. Late closure group: first CTx will be done within 4 (earliest) to 12 (latest) weeks after randomisation; stoma closure will be done 4 weeks after end of CTx. Randomisation will be performed around day 7 after LAR (after exclusion of an anastomotic leakage). To reach the statistically calculated goal of 257 recruited patients, at least 128 patients have to be randomised into each trial arm. W: weeks, M: months, OP: operation, *: after randomisation

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BMC Cancer

ISSN: 1471-2407

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