Fig. 10

Effect of long term culturing HMEC spheres in OPG rich medium on the copy number of genes relevant to oncogenic pathways. a Schematic of culturing three generations of HMEC spheres in presence of rhOPG. b Copy number differences among HMEC, SUM149PT, and SUM1315MO2 adherent cells. c Copy number differences among HMEC, SUM149PT, and SUM1315MO2 spheres. d Comparison of copy number analysis of reference and inflammatory breast cancer tissue DNA. e Comparison of copy number analysis of HMEC spheres cultured for three generations in the absence or presence of 500 pg/ml rhOPG