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Table 4 Sept9 positivity of individuals with NED

From: Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case–control study

  

1/3 algorithm

2/3 algorithm

Variable

 

P

N

% (95 % CI)

p*

P

N

% (95 % CI)

p*

  

27

123

18

NR

27

123

18

NR

Sex

Female

11

64

15 (8–25)

0.4

2

73

3 (0–9)

0.44

 

Male

16

59

21 (13–32)

 

5

70

7 (2–15)

 

Age

≤65

12

86

12 (6–20)

0.015

2

96

2 (0–7)

0.05

 

>65

15

37

29 (17–43)

 

5

47

10 (3–21)

 

Hypertension

No

18

74

20 (12–29)

0.66

4

88

4 (1–11)

1.00

 

Yes

9

49

16 (7–27)

 

3

55

5 (1–14)

 

Diabetes

No

25

122

17 (11–24)

0.08

6

141

4 (2–9)

0.13

 

Yes

2

1

67 (9–99)

 

1

2

33 (0–91)

 

Arteriosclerosis

No

17

99

15 (9–22)

0.07

2

114

2 (0–6)

0.007

Yes

10

24

29 (12–39)

 

5

29

15 (5–31)

 

Respiratory disease

No

24

105

19 (12–26)

0.77

5

124

4 (1–8)

0.25

Yes

3

18

14 (3–36)

 

2

19

10 (1–30)

 

Arthritis

No

23

118

16 (11–23)

0.06

7

134

5 (2–10)

1.00

 

Yes

4

5

44 (14–79)

 

0

9

0 (0–34)

 

Smoke#

No

10

54

16 (8–27)

0.33

2

62

3 (0–11)

0.36

 

Yes

17

69

20 (12–30)

 

5

81

6 (2–13)

 

Alcohol##

Normal use

24

103

19 (12–27)

0.77

6

121

5 (2–10)

1.00

 

Abuse

3

20

13 (3–34)

 

1

22

4 (0–22)

 

BMI

<18,5

0

5

0 (0–52)

0.92

0

5

0 (0–52)

0.61

 

18,5 to 25

15

67

18 (11–28)

 

5

77

6 (2–14)

 
 

25 to 30

9

39

19 (9–33)

 

1

47

2 (0–11)

 
 

>30

3

12

20 (4–48)

 

1

14

7 (0–32)

 

Plasma volume

< 3.5 ml

20

64

24 (15–34)

0.05

6

78

7 (3–15)

0.14

3.5 ml

7

59

11 (4–21)

 

1

65

2 (0–8)

 
  1. *p-value, two-sided Fisher’s exact test, p<0.05 considered statistically significant
  2. NR Not relevant, P Positive, N Negative, % Positive fraction, NED No Evidence of Disease
  3. #Former smokers and current smokers pooled
  4. ##Abuse: Women > 7 units per week, Men >14 units per week