Table 2 Summary of Epi proColon test performance in a nested case-control cohort from the Endoscopy II population
1/3 algorithm | ||||
|---|---|---|---|---|
Diagnosis | Subjects (n) | Positive (n) | Negative (n) | Fraction (95 % CI) |
CRC | 128 | 93 | 35 | 0.73 (0.64–0.80) |
stage I | 35 | 13 | 22 | 0.37 (0.21–0.55) |
stage II | 35 | 32 | 3 | 0.91 (0.76–0.98) |
stage III | 30 | 23 | 7 | 0.77 (0.58–0.90) |
stage IV | 28 | 25 | 3 | 0.89 (0.72–0.98) |
Non-CRC | 171 | 30 | 141 | 0.18 (0.12–0.24) |
Adenoma | 21 | 3 | 18 | 0.14 (0.03–0.63) |
NED | 150 | 27 | 123 | 0.18 (0.12–0.25) |
2/3 algorithm | ||||
CRC | 128 | 75 | 53 | 0.59 (0.50–0.67) |
stage I | 35 | 6 | 29 | 0.17 (0.07–0.34) |
stage II | 35 | 26 | 9 | 0.74 (0.57–0.88) |
stage III | 30 | 19 | 11 | 0.63 (0.44–0.80) |
stage IV | 28 | 24 | 4 | 0.86 (0.67–0.96) |
Non-CRC | 171 | 7 | 164 | 0.04 (0.02–0.08) |
Adenoma | 21 | 0 | 21 | 0.00 (0.00–0.16) |
NED | 150 | 7 | 143 | 0.05 (0.02–0.09) |