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Table 1 Inflammatory milieu within pancreatic tissue is predictive of malignancy

From: The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival

 

Normal pancreas (n = 6)

Pancreatitis (n = 9)

Pancreatic cancer (n = 36)

P value nonmalignant vs. Pancreatic cancer

P value pancreatitis vs. Pancreatic cancer

Growth factors

     

FGF-2

761 (221)

951 (187)

1674 (177)

.009

.063

PDGF-BB

117 (46)

102 (48)

244 (63)

.026

.022

VEGF

151 (46)

76 (20)

252 (59)

.119

.046

Chemokines

     

Eotaxin

21.8 (12.8)

21.4 (12.9)

90.4 (16.3)

<.001

.002

Fractalkine

55.1 (12.8)

43.0 (9.4)

71.1 (3.6)

.010

.009

Gro

163 (67)

463 (296)

531 (87)

.007

.043

IP-10

69 (33)

70 (32)

620 (148)

<.001

<.001

MCP1

437 (136)

378 (104)

1615 (302)

<.001

<.001

MCP3

4.7 (1.9)

2.5 (0.8)

16.6 (2.8)

<.001

<.001

MDC

27 (11)

70 (36)

143 (17)

<.001

.009

MIP-1α

14.3 (4.9)

16.9 (7.6)

37.9 (4.6)

.001

.009

MIP-1β

22.1 (9.4)

14.3 (5.0)

38.4 (6.1)

.007

.008

RANTES

766 (261)

1066 (228)

1929 (235)

.032

.178

Cytokines

     

GM-CSF

4.1 (2.0)

1.4 (0.3)

14.0 (3.9)

<.001

<.001

IFNα2

13.0 (2.7)

8.7 (2.3)

19.9 (2.4)

.013

.012

IL-1α

1.8 (0.5)

3.2 (0.6)

12.2 (2.0)

<.001

.003

IL-1RA

157 (144)

46 (21)

500 (96)

<.001

<.001

IL-1β

0.6 (0.1)

0.9 (0.1)

1.3 (0.2)

.032

.262

IL-6

13.3 (5.3)

5.8 (2.1)

71.8 (23.3)

<.001

<.001

IL-7

3.9 (1.0)

4.5 (1.0)

10.4 (0.8)

<.001

<.001

IL-8

160 (154)

61 (37)

848 (161)

<.001

.002

IL-15

1.7 (0.2)

2.0 (0.3)

3.5 (0.4)

.001

.021

TNFα

1.6 (0.7)

1.4 (0.4)

3.3 (0.4)

.002

.010

  1. Concentrations expressed as mean (SE) in units of pg/mg protein. All significant comparisons are shown for which P < 0.05 using the Mann Whitney U test