Skip to main content

Table 2 Clinical and biological characteristics of the two GIST patients series according to KITL541

From: KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome

Clinical and biological characteristics KIT L541 KIT M541 P b
N 24 85  
Median size (mm) 50 (17–240) 60 (20–400)  
Location    
 Stomach 12 (50 %) 48 (56 %) 0.6
 Small bowel 7 (29 %) 28 (33 %) 1
Mitotic index    
  ≤ 5 11 (50 %)a 46 (54 %) 0.8
 6–10 2 (9 %)a 15 (18 %) 0.5
  > 10 9 (41 %)a 24 (28 %) 0.4
Mutation status    
KIT Mutations 15 (75 %)a 49 (70 %)a 0.8
KIT exon 11 10 (50 %)a 42 (60 %)a 0.5
KIT exon 9 3 (15 %)a 5 (7 %)a 0.4
KIT exon 13 2 (10 %)a 0 n/a
KIT exon 17 0 2 (3 %)a n/a
PDGFRA Mutations 2 (10 %)a 9 (13 %)a 1
PDGFRA exon 18 D842V 1 8  
 Wild Type 3 (15 %)a 12 (17 %)a 1
 Undetermined 4 15  
Stage of the disease at diagnosis    
 Localized 15 (62 %) 72 (85 %) 0.02
 Metastatic (or locally advanced/unresectable) 9 (38 %) 13 (15 %)
  1. aPercentages are determined on the evaluable cases
  2. bChi-square test or Fisher’s exact test were applied as appropriate to check for differences according to the presence of KITL541