Table 2 Clinical and biological characteristics of the two GIST patients series according to KIT^L541

N

24

85

Median size (mm)

50 (17–240)

60 (20–400)

Location

 Stomach

12 (50 %)

48 (56 %)

0.6

 Small bowel

7 (29 %)

28 (33 %)

1

Mitotic index

  ≤ 5

11 (50 %)^a

46 (54 %)

0.8

 6–10

2 (9 %)^a

15 (18 %)

0.5

  > 10

9 (41 %)^a

24 (28 %)

0.4

Mutation status

 KIT Mutations

15 (75 %)^a

49 (70 %)^a

0.8

 KIT exon 11

10 (50 %)^a

42 (60 %)^a

0.5

 KIT exon 9

3 (15 %)^a

5 (7 %)^a

0.4

 KIT exon 13

2 (10 %)^a

0

n/a

 KIT exon 17

0

2 (3 %)^a

n/a

 PDGFRA Mutations

2 (10 %)^a

9 (13 %)^a

1

 PDGFRA exon 18 D842V

1

8

 Wild Type

3 (15 %)^a

12 (17 %)^a

1

 Undetermined

4

15

Stage of the disease at diagnosis

 Localized

15 (62 %)

72 (85 %)

0.02

 Metastatic (or locally advanced/unresectable)

9 (38 %)

13 (15 %)