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Table 1 Baseline characteristics of the two retrospective series of GIST

From: KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome

Characteristics First series of resected primary GIST Second series of metastatic or locally advanced at diagnosis GIST
N 87 22
 Male 42 13
 Female 45 9
Age (years) 65 (22–84) 64 (39–79)
Median size (mm) 58 (17–400) 90 (45–240)
Location   
 Stomach 52 (60 %) 8 (36 %)
 Small bowel 24 (28 %) 11 (50 %)
 Other locations 11 (12 %) 3 (14 %)
Mitotic index per 50 HPF   
  ≤ 5 51 (59 %)a 5 (26 %)a
 6–10 12 (14 %)a 4 (21 %)a
  > 10 23 (27 %)a 10 (52 %)a
 Unknown 1 3
Mutation status   
 KIT ex 11 40 (54 %)a 12 (75 %)a
 KIT ex 9 5 (7 %)a 3 (19 %)a
 KIT ex 13 1 (1 %)a 1 (6 %)a
 KIT ex 17 2 (3 %)a 0
 PDGFRA ex 18 11 (15 %)a 0
 D842V 9 0
 No mutation on KIT or PDGFRA hotspots 15 (20 %)a 0
 Unknown 13 6
Prevalence of the variant KITL541 15 (17 %) 9 (41 %)
  1. aPercentages are determined on the evaluable cases
  2. HPF high-power field