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Table 2 The prognostic significance of Epstein-Barr virus infection in gastric cancer by prespecified study characteristics in different subgroups

From: Prognostic significance of Epstein-Barr virus infection in gastric cancer: a meta-analysis

Stratified analysis No. of Studies Test of association     Test of heterogeneity
   Pooled HR (95 % CI) Z P-value Model X 2 P-value I2 (%)
Overall 24 0.67 (0.55,0.79) 11.18 <0.001 fixed-effects model 26.39 0.283 12.8
Region         
 Asia 13 0.62 (0.48,0.75) 9.18 <0.001 fixed-effects model 19.65 0.074 38.9
 Europe 5 0.87 (0.52,1.23) 4.87 <0.001 fixed-effects model 1.37 0.85 0
 Americas 6 0.93 (0.53,1.34) 4.53 <0.001 fixed-effects model 1.76 0.881 0
Statistical methodology         
 Univariate analysis 21 0.62 (0.50,0.74) 9.81 <0.001 fixed-effects model 18.52 0.553 0
 Multivariate analysis 3 1.13 (0.76,1.50) 5.95 <0.001 fixed-effects model 1.36 0.506 0
Quality assessment         
 High quality 21 0.67 (0.55,0.79) 10.93 <0.001 fixed-effects model 25.77 0.174 22.4
 Low quality 3 0.83 (0.16,1.51) 2.41 0.016 fixed-effects model 0.4 0.819 0
  1. Abbreviations: EBV Epstein - Barr virus, HR hazard ratio, CI confidence interval