Table 2 BRAF mutation in lung cancers, CRCs and melanomas

Activated

G464V (c.1391G > T)

2

2

G466A (c.1397G > C)

2

1

3

G469A (c.1406G > C)

1

1

N581S (c.1742A > G)

2

2

L597Q (c.1790 T > A)

1

1

L597R (c.1790 T > G)

1

1

V600E (c.1799 T > A)^a

7

27

44

78

V600K (c.1798_1799delinsAA)

7

7

V600R (c.1798_1799GT > AG)

1

1

K601E (c.1801A > G)

3

2

5

Total

15 (2.9 %)

29 (11 %)

57 (38 %)

101

Impaired

G466R (c.1396G > A)

1

1

G466V (c.1397G > T)

1

1

2

Y472C (c.1415A > G)

1

1

D594E (c.1782 T > G)

1

1

D594G (c.1781A > G)

4

3

1

8

D594H (c.1780G > C)

1

1

D594N (c.1780G > A)

2

1

2

5

G596R (c.1786G > C)

1

1

Total

10 (2.0 %)

5 (1.8 %)

5 (3.3 %)

20

Unknown

T440I (c.1319C > T)^b

1

1

S467L (c.1400C > T)

1

1

G469E (c.1406G > A)

2

2

G469R (c.1405G > A)

1

1

G469S (c.1405_1406delinsTC)

1

1

G469V (c.1406G > T)

1

1

2

L584F (c.1750C > T)

1

1

L588F (c.1762C > T)

1

1

V600_K601delinsE (c.1799_1801del)^b

1

1

S605I (c.1814G > T)^b

1

1

Q609L (c.1825_1826delinsTT)^b

1

1

E611Q (c.1831G > C)^b

1

1

Total

8 (1.6 %)

0

6 (3.9 %)

14

Total

33 (6.5 %)

34 (12 %)

68/67^c (44 %)

135/134^c