Fig. 1From: Clinical detection and categorization of uncommon and concomitant mutations involving BRAFActivation of MAPK pathway by kinase-activated, kinase-impaired and kinase-silent BRAF mutants through different mechanisms. Approved or potential targeted therapies are selected based on kinase activity of the BRAF mutants and concomitant mutations of the BRAF and RAS (KRAS or NRAS) genes. SBI: selective BRAF inhibitors; MEKI: MEK inhibitors; CI: CRAF inhibitorsBack to article page