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Table 2 Gene ontology (GO) analysis of genes selected from transcripts differentiating the clinical subgroups of pilocytic astrocytomas

From: Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features

GO ID GO Term Observed in the selected subset Expected in the selected subset Observed/Expected
Cellular components
GO:0031225 Anchored to membrane 6 1.66 3.62
GO:0005925 Focal adhesion 6 1.72 3.48
GO:0009897 External side of plasma membrane 6 1.77 3.4
GO:0005924 Cell-substrate adherens junction 6 1.77 3.4
GO:0031253 Cell projection membrane 5 1.52 3.28
GO:0005912 Adherens junction 9 2.83 3.19
GO:0030055 Cell-substrate junction 6 1.92 3.12
GO:0043235 Receptor complex 5 1.74 2.87
GO:0044297 Cell body 6 2.27 2.64
GO:0043025 Neuronal cell body 6 2.27 2.64
Molecular functions
GO:0019842 Vitamin binding 6 1.84 3.26
GO:0019900 Kinase binding 9 2.9 3.1
GO:0019901 Protein kinase binding 7 2.3 3.05
GO:0003714 Transcription corepressor activity 6 2.25 2.66
GO:0008234 Cysteine-type peptidase activity 6 2.34 2.56
GO:0042277 Peptide binding 5 2.3 2.18
Biological processes
GO:0032677 Regulation of interleukin-8 production 6 0.37 16.38
GO:0032637 Interleukin-8 production 6 0.4 15.12
GO:0003081 Regulation of systemic arterial blood pressure by renin-angiotensin 5 0.34 14.89
GO:0001990 Regulation of systemic arterial blood pressure by hormone 5 0.43 11.7
GO:0002221 Pattern recognition receptor signaling pathway 7 0.82 8.49
GO:0003044 Regulation of systemic arterial blood pressure mediated by a chemical signal 5 0.61 8.19
GO:0002758 Innate immune response-activating signal transduction 7 0.89 7.91
GO:0002218 Activation of innate immune response 7 0.89 7.91
GO:0003073 Regulation of systemic arterial blood pressure 5 0.64 7.8
GO:0050886 Endocrine process 5 0.73 6.83
GO:0021953 Central nervous system neuron differentiation 5 0.76 6.55
GO:0050731 Positive regulation of peptidyl-tyrosine phosphorylation 6 0.95 6.34
GO:0050729 Positive regulation of inflammatory response 5 0.82 6.07
GO:0002768 Immune response-regulating cell surface receptor signaling pathway 7 1.19 5.88
GO:0050864 Regulation of B cell activation 6 1.07 5.62
GO:0050671 Positive regulation of lymphocyte proliferation 6 1.07 5.62
GO:0070665 Positive regulation of leukocyte proliferation 6 1.1 5.46
GO:0048839 Inner ear development 8 1.47 5.46
GO:0032946 Positive regulation of mononuclear cell proliferation 6 1.1 5.46
GO:0002429 Immune response-activating cell surface receptor signaling pathway 6 1.13 5.31
GO:0050730 Regulation of peptidyl-tyrosine phosphorylation 7 1.47 4.78
GO:0050670 Regulation of lymphocyte proliferation 8 1.71 4.68
GO:0070663 Regulation of leukocyte proliferation 8 1.74 4.6
GO:0032944 Regulation of mononuclear cell proliferation 8 1.74 4.6
GO:0042129 Regulation of T cell proliferation 5 1.13 4.43
GO:0032103 Positive regulation of response to external stimulus 7 1.62 4.33
GO:0002706 Regulation of lymphocyte mediated immunity 5 1.19 4.2
GO:0050727 Regulation of inflammatory response 6 1.47 4.1
GO:0043583 Ear development 8 1.98 4.03
GO:0009310 Amine catabolic process 8 1.98 4.03
GO:0090047 Positive regulation of transcription regulator activity 5 1.31 3.81
GO:0051091 Positive regulation of transcription factor activity 5 1.31 3.81
GO:0008217 Pegulation of blood pressure 7 1.86 3.76
GO:0051606 Detection of stimulus 6 1.65 3.64
GO:0021537 Telencephalon development 8 2.2 3.64
GO:0009064 Glutamine family amino acid metabolic process 5 1.37 3.64
GO:0002822 Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5 1.37 3.64
GO:0002703 Regulation of leukocyte mediated immunity 5 1.37 3.64
GO:0050870 Positive regulation of T cell activation 7 1.95 3.58
GO:0002819 Regulation of adaptive immune response 5 1.4 3.56
GO:0043388 Positive regulation of DNA binding 5 1.43 3.49
GO:0051099 Positive regulation of binding 6 1.74 3.45
GO:0009063 Cellular amino acid catabolic process 6 1.74 3.45
GO:0043410 Positive regulation of MAPKKK cascade 5 1.5 3.34
GO:0090046 Regulation of transcription regulator activity 8 2.47 3.24
GO:0051090 Regulation of transcription factor activity 8 2.47 3.24
GO:0048562 Embryonic organ morphogenesis 8 2.53 3.16
GO:0046651 Lymphocyte proliferation 8 2.53 3.16
GO:0042113 B cell activation 8 2.53 3.16
GO:0018108 Peptidyl-tyrosine phosphorylation 8 2.53 3.16
GO:0045927 Positive regulation of growth 5 1.62 3.09
GO:0018212 Peptidyl-tyrosine modification 8 2.59 3.08
GO:0070661 Leukocyte proliferation 8 2.62 3.05
GO:0032943 Mononuclear cell proliferation 8 2.62 3.05
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger 5 1.65 3.03
GO:0002237 Response to molecule of bacterial origin 6 1.98 3.02
GO:0046395 Carboxylic acid catabolic process 8 2.66 3.01
GO:0016054 Organic acid catabolic process 8 2.66 3.01
GO:0042098 T cell proliferation 5 1.68 2.98
GO:0042445 Hormone metabolic process 7 2.38 2.94
GO:0019935 Cyclic-nucleotide-mediated signaling 6 2.04 2.93
GO:0009952 Anterior/posterior pattern formation 6 2.08 2.89
GO:0010001 Glial cell differentiation 5 1.77 2.82
GO:0009266 Response to temperature stimulus 5 1.77 2.82
GO:0071375 Cellular response to peptide hormone stimulus 6 2.14 2.81
GO:0030217 T cell differentiation 9 3.27 2.76
GO:0045664 Regulation of neuron differentiation 9 3.33 2.71
GO:0050863 Regulation of T cell activation 8 2.99 2.67
GO:0001934 Positive regulation of protein amino acid phosphorylation 6 2.29 2.62
GO:0051222 Positive regulation of protein transport 5 1.95 2.56
GO:0002460 Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7 2.87 2.44
GO:0043408 Regulation of MAPKKK cascade 7 2.9 2.41
GO:0042327 Positive regulation of phosphorylation 6 2.5 2.4
GO:0034097 Response to cytokine stimulus 6 2.5 2.4
GO:0002250 Adaptive immune response 7 2.93 2.39
GO:0002449 Lymphocyte mediated immunity 6 2.53 2.37
GO:0050953 Sensory perception of light stimulus 7 3.02 2.32
GO:0007601 Visual perception 7 3.02 2.32
GO:0045937 Positive regulation of phosphate metabolic process 6 2.59 2.31
GO:0042063 Gliogenesis 5 2.17 2.31
GO:0010562 Positive regulation of phosphorus metabolic process 6 2.59 2.31
GO:0007411 Axon guidance 5 2.17 2.31
GO:0043010 Camera-type eye development 5 2.2 2.28
GO:0009617 Response to bacterium 8 3.51 2.28
GO:0002697 Regulation of immune effector process 5 2.2 2.28
GO:0032870 Cellular response to hormone stimulus 8 3.54 2.26
GO:0071495 Cellular response to endogenous stimulus 8 3.57 2.24
GO:0030855 Epithelial cell differentiation 5 2.23 2.24
GO:0030258 Lipid modification 5 2.23 2.24
GO:0043122 Regulation of I-kappaB kinase/NF-kappaB cascade 6 2.78 2.16
GO:0008643 Carbohydrate transport 5 2.32 2.16
GO:0048568 Embryonic organ development 8 3.72 2.15
GO:0051239 Regulation of multicellular organismal process 72 33.82 2.13
GO:0008624 Induction of apoptosis by extracellular signals 5 2.38 2.1
GO:0007399 Nervous system development 84 41.36 2.03
GO:0002376 Immune system process 80 39.37 2.03
GO:0003002 Regionalization 8 3.97 2.02
  1. The number of genes changed in each category was compared with the number of expected occurrences. Only GO classes and parent classes with at least five observations in the selected subset and with an ’observed vs. expected’ ratio of at least two were shown