Table 2 Gene ontology (GO) analysis of genes selected from transcripts differentiating the clinical subgroups of pilocytic astrocytomas
GO ID | GO Term | Observed in the selected subset | Expected in the selected subset | Observed/Expected |
|---|---|---|---|---|
Cellular components | ||||
GO:0031225 | Anchored to membrane | 6 | 1.66 | 3.62 |
GO:0005925 | Focal adhesion | 6 | 1.72 | 3.48 |
GO:0009897 | External side of plasma membrane | 6 | 1.77 | 3.4 |
GO:0005924 | Cell-substrate adherens junction | 6 | 1.77 | 3.4 |
GO:0031253 | Cell projection membrane | 5 | 1.52 | 3.28 |
GO:0005912 | Adherens junction | 9 | 2.83 | 3.19 |
GO:0030055 | Cell-substrate junction | 6 | 1.92 | 3.12 |
GO:0043235 | Receptor complex | 5 | 1.74 | 2.87 |
GO:0044297 | Cell body | 6 | 2.27 | 2.64 |
GO:0043025 | Neuronal cell body | 6 | 2.27 | 2.64 |
Molecular functions | ||||
GO:0019842 | Vitamin binding | 6 | 1.84 | 3.26 |
GO:0019900 | Kinase binding | 9 | 2.9 | 3.1 |
GO:0019901 | Protein kinase binding | 7 | 2.3 | 3.05 |
GO:0003714 | Transcription corepressor activity | 6 | 2.25 | 2.66 |
GO:0008234 | Cysteine-type peptidase activity | 6 | 2.34 | 2.56 |
GO:0042277 | Peptide binding | 5 | 2.3 | 2.18 |
Biological processes | ||||
GO:0032677 | Regulation of interleukin-8 production | 6 | 0.37 | 16.38 |
GO:0032637 | Interleukin-8 production | 6 | 0.4 | 15.12 |
GO:0003081 | Regulation of systemic arterial blood pressure by renin-angiotensin | 5 | 0.34 | 14.89 |
GO:0001990 | Regulation of systemic arterial blood pressure by hormone | 5 | 0.43 | 11.7 |
GO:0002221 | Pattern recognition receptor signaling pathway | 7 | 0.82 | 8.49 |
GO:0003044 | Regulation of systemic arterial blood pressure mediated by a chemical signal | 5 | 0.61 | 8.19 |
GO:0002758 | Innate immune response-activating signal transduction | 7 | 0.89 | 7.91 |
GO:0002218 | Activation of innate immune response | 7 | 0.89 | 7.91 |
GO:0003073 | Regulation of systemic arterial blood pressure | 5 | 0.64 | 7.8 |
GO:0050886 | Endocrine process | 5 | 0.73 | 6.83 |
GO:0021953 | Central nervous system neuron differentiation | 5 | 0.76 | 6.55 |
GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | 6 | 0.95 | 6.34 |
GO:0050729 | Positive regulation of inflammatory response | 5 | 0.82 | 6.07 |
GO:0002768 | Immune response-regulating cell surface receptor signaling pathway | 7 | 1.19 | 5.88 |
GO:0050864 | Regulation of B cell activation | 6 | 1.07 | 5.62 |
GO:0050671 | Positive regulation of lymphocyte proliferation | 6 | 1.07 | 5.62 |
GO:0070665 | Positive regulation of leukocyte proliferation | 6 | 1.1 | 5.46 |
GO:0048839 | Inner ear development | 8 | 1.47 | 5.46 |
GO:0032946 | Positive regulation of mononuclear cell proliferation | 6 | 1.1 | 5.46 |
GO:0002429 | Immune response-activating cell surface receptor signaling pathway | 6 | 1.13 | 5.31 |
GO:0050730 | Regulation of peptidyl-tyrosine phosphorylation | 7 | 1.47 | 4.78 |
GO:0050670 | Regulation of lymphocyte proliferation | 8 | 1.71 | 4.68 |
GO:0070663 | Regulation of leukocyte proliferation | 8 | 1.74 | 4.6 |
GO:0032944 | Regulation of mononuclear cell proliferation | 8 | 1.74 | 4.6 |
GO:0042129 | Regulation of T cell proliferation | 5 | 1.13 | 4.43 |
GO:0032103 | Positive regulation of response to external stimulus | 7 | 1.62 | 4.33 |
GO:0002706 | Regulation of lymphocyte mediated immunity | 5 | 1.19 | 4.2 |
GO:0050727 | Regulation of inflammatory response | 6 | 1.47 | 4.1 |
GO:0043583 | Ear development | 8 | 1.98 | 4.03 |
GO:0009310 | Amine catabolic process | 8 | 1.98 | 4.03 |
GO:0090047 | Positive regulation of transcription regulator activity | 5 | 1.31 | 3.81 |
GO:0051091 | Positive regulation of transcription factor activity | 5 | 1.31 | 3.81 |
GO:0008217 | Pegulation of blood pressure | 7 | 1.86 | 3.76 |
GO:0051606 | Detection of stimulus | 6 | 1.65 | 3.64 |
GO:0021537 | Telencephalon development | 8 | 2.2 | 3.64 |
GO:0009064 | Glutamine family amino acid metabolic process | 5 | 1.37 | 3.64 |
GO:0002822 | Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 5 | 1.37 | 3.64 |
GO:0002703 | Regulation of leukocyte mediated immunity | 5 | 1.37 | 3.64 |
GO:0050870 | Positive regulation of T cell activation | 7 | 1.95 | 3.58 |
GO:0002819 | Regulation of adaptive immune response | 5 | 1.4 | 3.56 |
GO:0043388 | Positive regulation of DNA binding | 5 | 1.43 | 3.49 |
GO:0051099 | Positive regulation of binding | 6 | 1.74 | 3.45 |
GO:0009063 | Cellular amino acid catabolic process | 6 | 1.74 | 3.45 |
GO:0043410 | Positive regulation of MAPKKK cascade | 5 | 1.5 | 3.34 |
GO:0090046 | Regulation of transcription regulator activity | 8 | 2.47 | 3.24 |
GO:0051090 | Regulation of transcription factor activity | 8 | 2.47 | 3.24 |
GO:0048562 | Embryonic organ morphogenesis | 8 | 2.53 | 3.16 |
GO:0046651 | Lymphocyte proliferation | 8 | 2.53 | 3.16 |
GO:0042113 | B cell activation | 8 | 2.53 | 3.16 |
GO:0018108 | Peptidyl-tyrosine phosphorylation | 8 | 2.53 | 3.16 |
GO:0045927 | Positive regulation of growth | 5 | 1.62 | 3.09 |
GO:0018212 | Peptidyl-tyrosine modification | 8 | 2.59 | 3.08 |
GO:0070661 | Leukocyte proliferation | 8 | 2.62 | 3.05 |
GO:0032943 | Mononuclear cell proliferation | 8 | 2.62 | 3.05 |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | 5 | 1.65 | 3.03 |
GO:0002237 | Response to molecule of bacterial origin | 6 | 1.98 | 3.02 |
GO:0046395 | Carboxylic acid catabolic process | 8 | 2.66 | 3.01 |
GO:0016054 | Organic acid catabolic process | 8 | 2.66 | 3.01 |
GO:0042098 | T cell proliferation | 5 | 1.68 | 2.98 |
GO:0042445 | Hormone metabolic process | 7 | 2.38 | 2.94 |
GO:0019935 | Cyclic-nucleotide-mediated signaling | 6 | 2.04 | 2.93 |
GO:0009952 | Anterior/posterior pattern formation | 6 | 2.08 | 2.89 |
GO:0010001 | Glial cell differentiation | 5 | 1.77 | 2.82 |
GO:0009266 | Response to temperature stimulus | 5 | 1.77 | 2.82 |
GO:0071375 | Cellular response to peptide hormone stimulus | 6 | 2.14 | 2.81 |
GO:0030217 | T cell differentiation | 9 | 3.27 | 2.76 |
GO:0045664 | Regulation of neuron differentiation | 9 | 3.33 | 2.71 |
GO:0050863 | Regulation of T cell activation | 8 | 2.99 | 2.67 |
GO:0001934 | Positive regulation of protein amino acid phosphorylation | 6 | 2.29 | 2.62 |
GO:0051222 | Positive regulation of protein transport | 5 | 1.95 | 2.56 |
GO:0002460 | Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 7 | 2.87 | 2.44 |
GO:0043408 | Regulation of MAPKKK cascade | 7 | 2.9 | 2.41 |
GO:0042327 | Positive regulation of phosphorylation | 6 | 2.5 | 2.4 |
GO:0034097 | Response to cytokine stimulus | 6 | 2.5 | 2.4 |
GO:0002250 | Adaptive immune response | 7 | 2.93 | 2.39 |
GO:0002449 | Lymphocyte mediated immunity | 6 | 2.53 | 2.37 |
GO:0050953 | Sensory perception of light stimulus | 7 | 3.02 | 2.32 |
GO:0007601 | Visual perception | 7 | 3.02 | 2.32 |
GO:0045937 | Positive regulation of phosphate metabolic process | 6 | 2.59 | 2.31 |
GO:0042063 | Gliogenesis | 5 | 2.17 | 2.31 |
GO:0010562 | Positive regulation of phosphorus metabolic process | 6 | 2.59 | 2.31 |
GO:0007411 | Axon guidance | 5 | 2.17 | 2.31 |
GO:0043010 | Camera-type eye development | 5 | 2.2 | 2.28 |
GO:0009617 | Response to bacterium | 8 | 3.51 | 2.28 |
GO:0002697 | Regulation of immune effector process | 5 | 2.2 | 2.28 |
GO:0032870 | Cellular response to hormone stimulus | 8 | 3.54 | 2.26 |
GO:0071495 | Cellular response to endogenous stimulus | 8 | 3.57 | 2.24 |
GO:0030855 | Epithelial cell differentiation | 5 | 2.23 | 2.24 |
GO:0030258 | Lipid modification | 5 | 2.23 | 2.24 |
GO:0043122 | Regulation of I-kappaB kinase/NF-kappaB cascade | 6 | 2.78 | 2.16 |
GO:0008643 | Carbohydrate transport | 5 | 2.32 | 2.16 |
GO:0048568 | Embryonic organ development | 8 | 3.72 | 2.15 |
GO:0051239 | Regulation of multicellular organismal process | 72 | 33.82 | 2.13 |
GO:0008624 | Induction of apoptosis by extracellular signals | 5 | 2.38 | 2.1 |
GO:0007399 | Nervous system development | 84 | 41.36 | 2.03 |
GO:0002376 | Immune system process | 80 | 39.37 | 2.03 |
GO:0003002 | Regionalization | 8 | 3.97 | 2.02 |